{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:45:40Z","timestamp":1790660740586,"version":"4.1.0"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1P30AI094189"],"award-info":[{"award-number":["1P30AI094189"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R61AI161809"],"award-info":[{"award-number":["R61AI161809"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Unitaid","award":["2020-38-LONGEVITY"],"award-info":[{"award-number":["2020-38-LONGEVITY"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2023,7,18]]},"abstract":"<jats:p>Administration of tuberculosis preventive therapy (TPT) to individuals with latent tuberculosis infection is an important facet of global tuberculosis control. The use of long-acting injectable (LAI) drug formulations may simplify and shorten regimens for this indication.<\/jats:p>","DOI":"10.1128\/aac.00481-23","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T10:00:39Z","timestamp":1686736839000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Using Dynamic Oral Dosing of Rifapentine and Rifabutin to Simulate Exposure Profiles of Long-Acting Formulations in a Mouse Model of Tuberculosis Preventive Therapy"],"prefix":"10.1128","volume":"67","author":[{"given":"Yong S.","family":"Chang","sequence":"first","affiliation":[{"name":"Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Pertinez","sequence":"additional","affiliation":[{"name":"Centre of Excellence in Long-Acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Betoudji","sequence":"additional","affiliation":[{"name":"Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6946-1097","authenticated-orcid":true,"given":"Steven P.","family":"Rannard","sequence":"additional","affiliation":[{"name":"Centre of Excellence in Long-Acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Owen","sequence":"additional","affiliation":[{"name":"Centre of Excellence in Long-Acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1440-9889","authenticated-orcid":true,"given":"Eric L.","family":"Nuermberger","sequence":"additional","affiliation":[{"name":"Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9359-9144","authenticated-orcid":true,"given":"Nicole C.","family":"Ammerman","sequence":"additional","affiliation":[{"name":"Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"},{"name":"Department of Medical Microbiology and Infectious Diseases, University Medical Center Rotterdam, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Global tuberculosis report 2021.","author":"World Health Organization","year":"2021","unstructured":"World Health Organization. 2021. Global tuberculosis report 2021. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_3_3_2","volume-title":"The End TB Strategy.","author":"World Health Organization","year":"2015","unstructured":"World Health Organization. 2015. The End TB Strategy. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_3_4_2","volume-title":"WHO operational handbook on tuberculosis. Module 1: prevention: tuberculosis preventive treatment.","author":"World Health Organization","year":"2020","unstructured":"World Health Organization. 2020. WHO operational handbook on tuberculosis. Module 1: prevention: tuberculosis preventive treatment. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30216-X"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.17.0486"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.17.0515"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(87)90026-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac672"},{"key":"e_1_3_3_10_2","volume-title":"Mycobutin (R) (rifabutin) capsules, USP (FDA label).","author":"Pfizer Laboratories Div Phizer Inc","year":"2021","unstructured":"Pfizer Laboratories Div Phizer Inc. 2021. Mycobutin (R) (rifabutin) capsules, USP (FDA label). Pfizer, New York, NY."},{"key":"e_1_3_3_11_2","unstructured":"European Medicines Agency (EMA) Human Medicines Division. 2022. Committee for Orphan Medicinal Products (COMP) minutes for the meeting on 12-14 July 2022. EMA Human Medicines Division Amsterdam The Netherlands. https:\/\/www.ema.europa.eu\/en\/documents\/minutes\/minutes-comp-meeting-12-14-july-2022_en.pdf."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.6_Pt_1.1541"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02398-21"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32043-3"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.36.1502"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.10.2346"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw024"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.11.096644"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.10.0238"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201103-0397OC"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200905-0795OC"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806808"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01705-21"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/36.1.247"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200507-1072OC"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00912-12"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pit077"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.Supplement_1.S15"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa460"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00614-15"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00007-19"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250480397"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-5-2-165"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05293-11"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00388-19"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202012-4541OC"},{"key":"e_1_3_3_37_2","unstructured":"R Core Team. 2020. R: a language and environment for statistical computing. R Foundation for Statistical Computing Vienna Austria. https:\/\/www.R-project.org\/."},{"key":"e_1_3_3_38_2","unstructured":"Borchers HW. 2019. pracma: practical numerical math functions. R package version 2.2.9. https:\/\/CRAN.R-project.org\/package=pracma."},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E259"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103125"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02548-15"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00481-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00481-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T09:04:32Z","timestamp":1689671072000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00481-23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,18]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7,18]]}},"alternative-id":["10.1128\/aac.00481-23"],"URL":"https:\/\/doi.org\/10.1128\/aac.00481-23","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.04.12.536604","asserted-by":"object"}]},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,18]]},"assertion":[{"value":"2023-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00481-23"}}