{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:42:42Z","timestamp":1773283362030,"version":"3.50.1"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Among 254\n            <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n            isolates from a sexually transmitted infection (STI) clinic in northern Taiwan, 69 isolates were found to contain the mosaic\n            <jats:italic>penA<\/jats:italic>\n            (MA) gene and were associated with elevated cefixime and ceftriaxone MICs. Most of these MA gene-harboring isolates were also resistant to penicillin (71.4%) and ciprofloxacin (100%) and were from men who have sex with men (MSM) or from bisexual men (81.2%). Three major sequence types (ST835, ST2180, and ST2253) constituted 55.7% of these isolates. The major sequence types harboring the mosaic\n            <jats:italic>penA<\/jats:italic>\n            gene may represent major sexual networks responsible for the emergence\/introduction and the spread of the multidrug-resistant clones in Taiwan.\n          <\/jats:p>","DOI":"10.1128\/aac.00482-10","type":"journal-article","created":{"date-parts":[[2010,8,24]],"date-time":"2010-08-24T02:45:25Z","timestamp":1282617925000},"page":"4893-4895","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Characteristics and Dissemination of Mosaic Penicillin-Binding Protein 2-Harboring Multidrug-Resistant\n            <i>Neisseria gonorrhoeae<\/i>\n            Isolates with Reduced Cephalosporin Susceptibility in Northern Taiwan"],"prefix":"10.1128","volume":"54","author":[{"given":"Chung-Ter","family":"Huang","sequence":"first","affiliation":[{"name":"Research and Diagnostic Center, Centers for Disease Control"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muh-Yong","family":"Yen","sequence":"additional","affiliation":[{"name":"Taipei City Hospital, KunMing Branch"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing-Wai","family":"Wong","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan-Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Taipei City Hospital, KunMing Branch"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun-Yen","family":"Lin","sequence":"additional","affiliation":[{"name":"Research and Diagnostic Center, Centers for Disease Control"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Hui","family":"Liao","sequence":"additional","affiliation":[{"name":"Research and Diagnostic Center, Centers for Disease Control"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Research and Diagnostic Center, Centers for Disease Control"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.12.3744-3749.2002"},{"key":"e_1_3_2_3_2","first-page":"222","volume":"56","year":"2007","unstructured":"Centers for Disease Control and Prevention. 2007. Increase in gonorrhea\u2014eight western states, 2000-2005. MMWR Morb. Mortal. Wkly. Rep.56:222-225.","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"e_1_3_2_4_2","first-page":"pii:19330","volume":"14","year":"2009","unstructured":"de Vries, H. J., J. J. van der Helm, M. F. Schim van der Loeff, and A. P. van Dam. 2009. Multidrug-resistant Neisseria gonorrhoeae with reduced cefotaxime susceptibility is increasingly common in men who have sex with men, Amsterdam, the Netherlands. Euro Surveill.14:pii:19330.","journal-title":"Euro Surveill."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2005.04.004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2004.009415"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/426142"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.1.137-143.2005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00198-08"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01010-09"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00406-09"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp118"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2005.08.021"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01108-09"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/377500"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00306-07"},{"key":"e_1_3_2_17_2","first-page":"430","volume":"30","year":"2006","unstructured":"WHO Western Pacific Gonococcal Antimicrobial Surveillance Programme. 2006. Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific Region, 2005. Commun. Dis. Intell.30:430-433.","journal-title":"Commun. Dis. 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