{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:10:58Z","timestamp":1776773458754,"version":"3.51.2"},"reference-count":67,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1134284"],"award-info":[{"award-number":["OPP1134284"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,12,16]]},"abstract":"<jats:p>Optimal dosing of children with tuberculous meningitis (TBM) remains uncertain and is currently based on the treatment of pulmonary tuberculosis in adults. This study aimed to investigate the population pharmacokinetics of isoniazid, rifampin, pyrazinamide, and ethambutol in Vietnamese children with TBM, to propose optimal dosing in these patients, and to determine the relationship between drug exposure and treatment outcome. A total of 100 Vietnamese children with TBM were treated with an 8-month antituberculosis regimen.<\/jats:p>","DOI":"10.1128\/aac.00487-20","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T14:54:05Z","timestamp":1603896845000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Population Pharmacokinetic Properties of Antituberculosis Drugs in Vietnamese Children with Tuberculous Meningitis"],"prefix":"10.1128","volume":"65","author":[{"given":"Navarat","family":"Panjasawatwong","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Mahidol University, Bangkok, Thailand"},{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanaporn","family":"Wattanakul","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Hoglund","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Duc","family":"Bang","sequence":"additional","affiliation":[{"name":"Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Pouplin","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wichit","family":"Nosoongnoen","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vi Nguyen","family":"Ngo","sequence":"additional","affiliation":[{"name":"Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy N.","family":"Day","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"},{"name":"Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4566-4030","authenticated-orcid":false,"given":"Joel","family":"Tarning","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Global tuberculosis report","author":"WHO","year":"2019","unstructured":"WHO. 2019. Global tuberculosis report. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_2_3_2","first-page":"365","article-title":"Extrapulmonary tuberculosis: tuberculous meningitis new developments","volume":"15","author":"Galimi R","year":"2011","unstructured":"Galimi R. 2011. Extrapulmonary tuberculosis: tuberculous meningitis new developments. Eur Rev Med Pharmacol Sci 15:365\u2013386.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/798764"},{"key":"e_1_3_2_5_2","first-page":"658","article-title":"Tuberculosis immunology in children: diagnostic and therapeutic challenges and opportunities","volume":"8","author":"Lewinsohn D","year":"2004","unstructured":"Lewinsohn D, Gennaro M, Scholvinck L, Lewinsohn D. 2004. Tuberculosis immunology in children: diagnostic and therapeutic challenges and opportunities. Int J Tuber Lung Dis 8:658\u2013674.","journal-title":"Int J Tuber Lung Dis"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_2013_15"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05792-11"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.778"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.052175"},{"key":"e_1_3_2_10_2","first-page":"1106","article-title":"Rifampicin serum levels in childhood tuberculosis","volume":"13","author":"Thee S","year":"2009","unstructured":"Thee S, Detjen A, Wahn U, Magdorf K. 2009. Rifampicin serum levels in childhood tuberculosis. Int J Tuber Lung Dis 13:1106\u20131111.","journal-title":"Int J Tuber Lung Dis"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.22.9.686.34067"},{"key":"e_1_3_2_12_2","first-page":"1360","article-title":"Pharmacokinetics of ethambutol in children and adults with tuberculosis","volume":"8","author":"Zhu M","year":"2004","unstructured":"Zhu M, Burman W, Starke J, Stambaugh J, Steiner P, Bulpitt A, Ashkin D, Auclair B, Berning S, Jelliffe R, Jaresko G, Peloquin C. 2004. Pharmacokinetics of ethambutol in children and adults with tuberculosis. Int J Tuber Lung Dis 8:1360\u20131367.","journal-title":"Int J Tuber Lung Dis"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05429-11"},{"key":"e_1_3_2_14_2","first-page":"1099","article-title":"Pyrazinamide serum levels in childhood tuberculosis","volume":"12","author":"Thee S","year":"2008","unstructured":"Thee S, Detjen A, Wahn U, Magdorf K. 2008. Pyrazinamide serum levels in childhood tuberculosis. Int J Tuber Lung Dis 12:1099\u20131101.","journal-title":"Int J Tuber Lung Dis"},{"key":"e_1_3_2_15_2","volume-title":"Guidance for national tuberculosis programmes on the management of tuberculosis in children","author":"WHO","year":"2006","unstructured":"WHO. 2006. Guidance for national tuberculosis programmes on the management of tuberculosis in children. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky268"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0222-8"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.987"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13846"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00008-18"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.202"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1071"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1783"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00508-16"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00641-18"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-9120(95)02024-1"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0000000000000232"},{"key":"e_1_3_2_29_2","first-page":"1318","article-title":"Ethambutol dosage for the treatment of children: literature review and recommendations","volume":"10","author":"Donald P","year":"2006","unstructured":"Donald P, Maher D, Maritz J, Qazi S. 2006. Ethambutol dosage for the treatment of children: literature review and recommendations. Int J Tuber Lung Dis 10:1318\u20131330.","journal-title":"Int J Tuber Lung Dis"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-8206.2001.00044.x"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.03940.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt524"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.3.650"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00007-10"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00512-18"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/1179573517693802"},{"key":"e_1_3_2_37_2","first-page":"151","volume-title":"Drug transporters: volume 1: role and importance in ADME and drug development","author":"Dickens D","year":"2016","unstructured":"Dickens D, Radisch S, Pirmohamed M. 2016. Drug transporters at the blood-brain barrier, p 151\u2013183. In Nicholls G, Youdim K, Thurston D, Fox D (ed), Drug transporters: volume 1: role and importance in ADME and drug development, vol 1. RSC Publishing, Cambridge, United Kingdom."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.721"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.82"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1080\/004982597239994"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-5-3"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425250903483215"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12267"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1989.129"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky128"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-303720"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01830-15"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02625-16"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141002"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0862-7"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00274-11"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2014.09.002"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1923-2"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1470-x"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.027748"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.08.010"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1990.59"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1996.tb00178.x"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-2607(98)00067-4"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2003.11.003"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-007-9066-0"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11060824"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.06.011"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.48.113006.094708"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-011-9255-z"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-016-9487-8"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040573"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/psp.2013.18"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00487-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00487-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:51:37Z","timestamp":1645480297000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00487-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,16]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12,16]]}},"alternative-id":["10.1128\/AAC.00487-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.00487-20","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,16]]},"assertion":[{"value":"2020-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00487-20"}}