{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:51:39Z","timestamp":1771606299997,"version":"3.50.1"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>An experimental micellar formulation of 1:1.5 amphotericin B-sodium deoxycholate (AMB:DCH 1:1.5) was obtained and characterized to determine its aggregation state and particle size. The biodistribution, nephrotoxicity, and efficacy against pulmonary aspergillosis in a murine model were studied and compared to the liposomal commercial formulation of amphotericin B after intravenous administration. The administration of 5 mg\/kg AMB:DCH 1:1.5 presented 2.8-fold-higher lung concentrations (18.125 \u00b1 3.985 \u03bcg\/g after 6 daily doses) and lower kidney exposure (0.391 \u00b1 0.167 \u03bcg\/g) than liposomal commercial amphotericin B (6.567 \u00b1 1.536 and 5.374 \u00b1 1.157 \u03bcg\/g in lungs and kidneys, respectively). The different biodistribution of AMB:DCH micelle systems compared to liposomal commercial amphotericin B was attributed to their different morphologies and particle sizes. The efficacy study has shown that both drugs administered at 5 mg\/kg produced similar survival percentages and reductions of fungal burden. A slightly lower nephrotoxicity, associated with amphotericin B, was observed with AMB:DCH 1:1.5 than the one induced by the liposomal commercial formulation. However, AMB:DCH 1:1.5 reached higher AMB concentrations in lungs, which could represent a therapeutic advantage over liposomal commercial amphotericin B-based treatment of pulmonary aspergillosis. These results are encouraging to explore the usefulness of AMB:DCH 1:1.5 against this disease.<\/jats:p>","DOI":"10.1128\/aac.00489-18","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T09:32:52Z","timestamp":1525944772000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy, Biodistribution, and Nephrotoxicity of Experimental Amphotericin B-Deoxycholate Formulations for Pulmonary Aspergillosis"],"prefix":"10.1128","volume":"62","author":[{"given":"Alicia","family":"L\u00f3pez-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Universidad Complutense, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"P\u00e9rez-Cantero","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, 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