{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:13:11Z","timestamp":1792113191414,"version":"4.4.0"},"reference-count":45,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI145322"],"award-info":[{"award-number":["AI145322"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018983","name":"UV | Global Infectious Diseases Institute, University of Virginia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018983","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,8,16]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Clostridioides difficile<\/jats:named-content>\n            infection (CDI) is the fifth leading cause of death from nonmalignant gastrointestinal disease in the United States. The contribution of resistance to\n            <jats:named-content content-type=\"genus-species\">C. difficile<\/jats:named-content>\n            -active antibiotics to the outcomes of CDI is unclear.\n          <\/jats:p>","DOI":"10.1128\/aac.00489-22","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T13:02:21Z","timestamp":1658408541000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Influence of Binary Toxin Gene Detection and Decreased Susceptibility to Antibiotics among Clostridioides difficile Strains on Disease Severity: a Single-Center Study"],"prefix":"10.1128","volume":"66","author":[{"given":"Deiziane V. S.","family":"Costa","sequence":"first","affiliation":[{"name":"University of Virginia, Division of Infectious Diseases and International Health, Charlottesville, Virginia, USA"},{"name":"Federal University of Ceara, Department of Physiology and Pharmacology, Fortaleza, Ceara, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie V. S.","family":"Pham","sequence":"additional","affiliation":[{"name":"University of Virginia, School of Medicine, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Hays","sequence":"additional","affiliation":[{"name":"University of Virginia, Division of Gastroenterology and Hepatology, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Bolick","sequence":"additional","affiliation":[{"name":"University of Virginia, Division of Infectious Diseases and International Health, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia M.","family":"Goldbeck","sequence":"additional","affiliation":[{"name":"University of Virginia, School of Medicine, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda D.","family":"Poulter","sequence":"additional","affiliation":[{"name":"University of Virginia, Department of Pathology, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sook C.","family":"Hoang","sequence":"additional","affiliation":[{"name":"University of Virginia, Department of Surgery, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae H.","family":"Shin","sequence":"additional","affiliation":[{"name":"University of Virginia, Division of Infectious Diseases and International Health, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wu","sequence":"additional","affiliation":[{"name":"University of Virginia, Department of Biology, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4417-0445","authenticated-orcid":true,"given":"Cirle A.","family":"Warren","sequence":"additional","affiliation":[{"name":"University of Virginia, Division of Infectious Diseases and International Health, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.17597"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.08.063"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2016.21.29.30293"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-72799-8_1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-1078-y"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.26855"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617750809"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05161-11"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-012-2056-6"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1919490117"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.01.018"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000587"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.17103"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy252"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2014.08.002"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-019-03708-7"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.604986"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02584"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02250-16"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa912"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3819"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9102026"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz513"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00845-15"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep37865"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S162874"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00391-19"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13742"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.08.017"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-019-03756-z"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-020-04121-1"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910215"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-017-0191-z"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.057968-0"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa118"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-017-3075-8"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa297"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1884516"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy149"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.9.4316-4318.2004"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.12.5710-5714.2004"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-103"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118150"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5052"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00489-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00489-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T13:05:32Z","timestamp":1660655132000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00489-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,16]]}},"alternative-id":["10.1128\/aac.00489-22"],"URL":"https:\/\/doi.org\/10.1128\/aac.00489-22","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,16]]},"assertion":[{"value":"2022-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00489-22"}}