{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T05:07:21Z","timestamp":1648876041539},"reference-count":10,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We analyzed the evolution of viral tropism after 8 days of maraviroc monotherapy, i.e., we used the maraviroc clinical test (MCT), in 21 patients with and 14 without virological response to the drug (MCT\n            <jats:sup>+<\/jats:sup>\n            and MCT\n            <jats:sup>\u2212<\/jats:sup>\n            patients, respectively). No increases in CXCR4 inferred viral loads (X4IVLs) were observed in MCT\n            <jats:sup>+<\/jats:sup>\n            patients, while X4IVLs increased only in MCT\n            <jats:sup>\u2212<\/jats:sup>\n            patients, with X4IVLs of &gt;2 log\n            <jats:sub>10<\/jats:sub>\n            HIV RNA copies\/ml. These results shed light on the evolution of viral tropism under a CCR5 antagonist\n            <jats:italic>in vivo<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.00507-12","type":"journal-article","created":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T02:53:11Z","timestamp":1335840791000},"page":"3981-3983","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["HIV-1 Tropism Evolution after Short-Term Maraviroc Monotherapy in HIV-1-Infected Patients"],"prefix":"10.1128","volume":"56","author":[{"given":"Alejandro","family":"Gonzalez-Serna","sequence":"first","affiliation":[{"name":"Laboratorio de Inmunovirologia, Servicio Enfermedades Infecciosas, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Concepci\u00f3n","family":"Romero-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunovirologia, Servicio Enfermedades Infecciosas, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Ferrando-Martinez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmuno-Biolog\u00eda Molecular, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Genebat","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunovirologia, Servicio Enfermedades Infecciosas, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Vidal","sequence":"additional","affiliation":[{"name":"Hospital Universitari Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria \u00c1ngeles","family":"Mu\u00f1oz-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmuno-Biolog\u00eda Molecular, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Antonia","family":"Abad","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunovirologia, Servicio Enfermedades Infecciosas, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain"},{"name":"Departmento de Bioqu\u00edmica Cl\u00ednica, Instituto de Biomedicina de Sevilla (IBIS)\/Hospital Universitario Virgen del Roc\u00edo, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Leal","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunovirologia, Servicio Enfermedades Infecciosas, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezequiel","family":"Ruiz-Mateos","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunovirologia, Servicio Enfermedades Infecciosas, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"13th Eur. AIDS Conf.\/EACS","author":"Genebat M","year":"2011","unstructured":"GenebatM . 2011. Maraviroc clinical test (MCT) effectiveness for CCR5 prescription in clinical practice, abstr PE7.9\/8. 13th Eur. AIDS Conf.\/EACS, Belgrade, Serbia."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/157016210793499295"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/jac\/dkp293","article-title":"Correlation between the Trofile test and virological response to a short-term maraviroc exposure in HIV-infected patients","volume":"64","author":"Genebat M","year":"2009","unstructured":"GenebatM . 2009. Correlation between the Trofile test and virological response to a short-term maraviroc exposure in HIV-infected patients. J. Antimicrob. Chemother. 64:845\u2013849.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00953-10"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-9-199305010-00004"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e328331b929"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32830ebcd4"},{"key":"e_1_3_3_9_2","first-page":"94","article-title":"An enhanced sensitivity Trofile HIV coreceptor tropism assay for selecting patients for therapy with entry inhibitors targeting CCR5: a review of analytical and clinical studies","volume":"3","author":"Reeves JD","year":"2009","unstructured":"ReevesJD CoakleyE PetropoulosCJ WhitcombJM. 2009. An enhanced sensitivity Trofile HIV coreceptor tropism assay for selecting patients for therapy with entry inhibitors targeting CCR5: a review of analytical and clinical studies. J. Viral Entry 3:94\u2013102.","journal-title":"J. Viral Entry"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833c543f"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.10.4909-4920.2006"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00507-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00507-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T14:10:27Z","timestamp":1645452627000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00507-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1128\/AAC.00507-12"],"URL":"https:\/\/doi.org\/10.1128\/aac.00507-12","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"2012-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-04-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}