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Nitric oxide (NO) is a naturally produced free radical with proven bactericidal effect. In this study, Foley urinary catheters were impregnated with gaseous NO. The catheters demonstrated slow release of nitric oxide over a 14-day period. The charged catheters were rendered antiseptic, and as such, were able to prevent bacterial colonization and biofilm formation on their luminal and exterior surfaces. In addition, we observed that NO-impregnated catheters were able to inhibit the growth of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    within the surrounding media, demonstrating the ability to eradicate a bacterial concentration of up to 10\n                    <jats:sup>4<\/jats:sup>\n                    CFU\/ml.\n                  <\/jats:p>","DOI":"10.1128\/aac.00511-09","type":"journal-article","created":{"date-parts":[[2009,11,2]],"date-time":"2009-11-02T22:04:57Z","timestamp":1257199497000},"page":"273-279","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":84,"title":["Slow Release of Nitric Oxide from Charged Catheters and Its Effect on Biofilm Formation by\n                    <i>Escherichia coli<\/i>"],"prefix":"10.1128","volume":"54","author":[{"given":"Gilly","family":"Regev-Shoshani","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases"},{"name":"Department of Medicine, Division of Respiratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yossef","family":"Av-Gay","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases"},{"name":"Department of Microbiology and Immunology"},{"name":"Enox Biopharma Inc., 3849 13th Avenue West, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92405-8"},{"key":"e_1_3_2_3_2","unstructured":"Biofilm inhibiting catheters and tubings. 2009"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2000.917307.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.6.2352-2355.2005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.24.8161-8163.2004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1318"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.5.2341-2349.2003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn006"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.Supplement_2.S162"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119473"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2005.08.003"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2005.01.006"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.08.020"},{"key":"e_1_3_2_16_2","first-page":"163","volume":"322","year":"2008","unstructured":"Hatt, J. 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