{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T19:26:08Z","timestamp":1776799568220,"version":"3.51.2"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["320030_175585"],"award-info":[{"award-number":["320030_175585"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,10,18]]},"abstract":"<jats:p>\n            Opisthorchiasis due to the liver fluke\n            <jats:named-content content-type=\"genus-species\">Opisthorchis felineus<\/jats:named-content>\n            is highly prevalent in rural regions of Western Siberia, causing severe liver and bile duct maladies. Praziquantel administered as a three-dose regimen is the only drug used to treat\n            <jats:named-content content-type=\"genus-species\">O. felineus<\/jats:named-content>\n            -infected individuals. A simpler single-dose treatment might serve as an alternative. The aim of this study was to compare the pharmacokinetic (PK) properties of single, ascending doses of praziquantel compared to multiple dosing in patients infected with\n            <jats:named-content content-type=\"genus-species\">O. felineus<\/jats:named-content>\n            to contribute to updated treatment guidelines.\n          <\/jats:p>","DOI":"10.1128\/aac.00526-22","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T13:01:06Z","timestamp":1662987666000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacokinetics of Ascending Doses of Praziquantel in Adults Infected with Opisthorchis felineus in Western Siberia, Russian Federation"],"prefix":"10.1128","volume":"66","author":[{"given":"Alexandra","family":"Probst","sequence":"first","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Allschwil, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Allschwil, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga S.","family":"Fedorova","sequence":"additional","affiliation":[{"name":"Siberian State Medical University, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia V.","family":"Mazeina","sequence":"additional","affiliation":[{"name":"Siberian State Medical University, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-0733","authenticated-orcid":true,"given":"Tatiana S.","family":"Sokolova","sequence":"additional","affiliation":[{"name":"Siberian State Medical University, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Golovach","sequence":"additional","affiliation":[{"name":"Siberian State Medical University, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-3521","authenticated-orcid":true,"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Allschwil, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2013.01.005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1110.050614"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00012-09"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2013.07.007"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2016.07.010"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008421"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trv085"},{"key":"e_1_3_2_9_2","first-page":"19","article-title":"An analysis of 4 strategies for the praziquantel treatment of persons infested with Opisthorchis felineus under conditions excluding reinfestation","author":"Bronshte\u012dn AM","year":"1988","unstructured":"Bronshte\u012dn AM, Ozeretskovskaia NN, Panteleeva EI, Pliushcheva GL, Gitsu GA. 1988. An analysis of 4 strategies for the praziquantel treatment of persons infested with Opisthorchis felineus under conditions excluding reinfestation. Med Parazitol (Mosk) 19\u201324. https:\/\/pubmed.ncbi.nlm.nih.gov\/3252134\/.","journal-title":"Med Parazitol (Mosk)"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008649"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2478\/s11686-019-00149-2"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-019-02663-8"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03874.x"},{"key":"e_1_3_2_14_2","first-page":"717","article-title":"Pharmacokinetics of praziquantel in patients with opisthorchiasis","volume":"24","author":"Na Bangchang K","year":"1993","unstructured":"Na Bangchang K, Karbwang J, Pungpak S, Radomyos B, Bunnag D. 1993. Pharmacokinetics of praziquantel in patients with opisthorchiasis. Southeast Asian J Trop Med Public Health 24:717\u2013723.","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004700"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw785"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.10.011"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-021-09791-8"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt491"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920006774832569"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(90)90333-a"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.51.809"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-198810010-00008"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12601"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02741-14"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-018-9601-1"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.07.036"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02253-17"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02489-18"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008323754"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.07.007"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100226"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2010.01.007"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00526-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00526-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T13:33:17Z","timestamp":1666099997000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00526-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,18]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10,18]]}},"alternative-id":["10.1128\/aac.00526-22"],"URL":"https:\/\/doi.org\/10.1128\/aac.00526-22","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,18]]},"assertion":[{"value":"2022-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00526-22"}}