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Previous studies have shown that the combinations of a carbapenem and a second-generation \u03b2-lactamase inhibitor are effective\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      , in macrophages, and in zebrafish embryos. We report here that imipenem combined with avibactam is also effective in a C3HeB\/FeJ mouse model of infection in reducing bacterial burden in organs. 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