{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:19:45Z","timestamp":1753881585285,"version":"3.41.2"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n            Single-dose primaquine (PQ) clears mature gametocytes and reduces the transmission of\n            <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n            after artemisinin combination therapy. Genetic variation in\n            <jats:italic>CYP2D6<\/jats:italic>\n            , the gene producing the drug-metabolizing enzyme cytochrome P450 2D6 (CYP2D6), influences plasma concentrations of PQ and its metabolites and is associated with PQ treatment failure in\n            <jats:named-content content-type=\"genus-species\">Plasmodium vivax<\/jats:named-content>\n            malaria.\n          <\/jats:p>","DOI":"10.1128\/aac.00538-19","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T11:09:40Z","timestamp":1564744180000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["<i>CYP2D6<\/i>\n            Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum"],"prefix":"10.1128","volume":"63","author":[{"given":"Helmi","family":"Pett","sequence":"first","affiliation":[{"name":"Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands"},{"name":"Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Bradley","sequence":"additional","affiliation":[{"name":"MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Okebe","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit the Gambia at the London School of Hygiene and Tropical Medicine, Banjul, the Gambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alassane","family":"Dicko","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Centre, Faculty of Pharmacy and Faculty of Medicine and Dentistry, University of Science, Techniques and Technologies of Bamako, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred B.","family":"Tiono","sequence":"additional","affiliation":[{"name":"Public Health Department, Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bronner P.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Will","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Chen","sequence":"additional","affiliation":[{"name":"Malaria Elimination Initiative, Global Health Group, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjerstin","family":"Lanke","sequence":"additional","affiliation":[{"name":"Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Neuvonen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Liina","family":"Mustaniemi","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice C.","family":"Eziefula","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom"},{"name":"Brighton and Sussex Centre for Global Health Research, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roly","family":"Gosling","sequence":"additional","affiliation":[{"name":"Malaria Elimination Initiative, Global Health Group, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"D\u2019Alessandro","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit the Gambia at the London School of Hygiene and Tropical Medicine, Banjul, the Gambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Drakeley","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Niemi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2666-094X","authenticated-orcid":false,"given":"Teun","family":"Bousema","sequence":"additional","affiliation":[{"name":"Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands"},{"name":"Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00479-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70268-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0581-y"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.10.032"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix237"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30044-6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.1449"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389200215666140202215316"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-003-0832-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2165\/11318030-000000000-00000"},{"key":"e_1_3_3_12_2","unstructured":"Pharmacogene Variation Consortium. 2018. CYP2D6. https:\/\/www.pharmvar.org\/gene\/CYP2D6. Accessed 19 June 2019."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1301936"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-212"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1632-8"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2271-z"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0441-1"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2010.08.005"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2012.01.001"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190272"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy014"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1341-3"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02590-16"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz134"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03704-14"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199937020-00002"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep09257"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00312"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2015.06.007"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000484380"},{"key":"e_1_3_3_31_2","volume-title":"New and redesigned TaqMan drug metabolism genotyping assays","author":"Thermo Fisher Scientific","year":"2014","unstructured":"Thermo Fisher Scientific. 2014. New and redesigned TaqMan drug metabolism genotyping assays. Thermo Fisher Scientific, Waltham, MA. https:\/\/www.thermofisher.com\/content\/dam\/LifeTech\/Documents\/PDFs\/PG1510-PJ7830-CO018663-New-DME-Assays-update-Americas-FLR.pdf. Accessed 11 March 2019."},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/emph\/eot010"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0777-6"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1329-z"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2004.03.018"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076316"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100406"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1145-5"},{"key":"e_1_3_3_39_2","volume-title":"Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity","author":"World Health Organization","year":"2011","unstructured":"World Health Organization. 2011 Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. WHO\/NMH\/NHD\/MNM\/11.1. World Health Organization, Geneva, Switzerland."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00538-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00538-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:36:02Z","timestamp":1645479362000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00538-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1128\/AAC.00538-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.00538-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"type":"print","value":"0066-4804"},{"type":"electronic","value":"1098-6596"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"2019-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00538-19"}}