{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:35:27Z","timestamp":1789065327649,"version":"build-2803163510"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1ZIAHL006200"],"award-info":[{"award-number":["1ZIAHL006200"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"HHS | NIH | NIH Clinical Center","doi-asserted-by":"publisher","award":["1ZIACL080012"],"award-info":[{"award-number":["1ZIACL080012"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,11,15]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Mycobacterium abscessus<\/jats:named-content>\n                    is an emerging nontuberculous\n                    <jats:named-content content-type=\"genus-species\">mycobacterium<\/jats:named-content>\n                    (NTM) pathogen infecting susceptible people with cystic fibrosis (CF) and non-CF bronchiectasis. Here, we demonstrated the activity of an FDA-approved drug, disulfiram, against drug-susceptible and drug-resistant\n                    <jats:named-content content-type=\"genus-species\">M. abscessus<\/jats:named-content>\n                    strains utilizing\n                    <jats:italic>in vitro<\/jats:italic>\n                    and intracellular macrophage assays and a zebrafish embryo infection model.\n                  <\/jats:p>","DOI":"10.1128\/aac.00539-22","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T13:01:05Z","timestamp":1664974865000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Disulfiram Is Effective against Drug-Resistant Mycobacterium abscessus in a Zebrafish Embryo Infection Model"],"prefix":"10.1128","volume":"66","author":[{"given":"Carlynn G.","family":"Winters","sequence":"first","affiliation":[{"name":"Laboratory of Chronic Airway Infection, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram M.","family":"Basnet","sequence":"additional","affiliation":[{"name":"Laboratory of Chronic Airway Infection, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige E.","family":"Faasuamalie","sequence":"additional","affiliation":[{"name":"Laboratory of Chronic Airway Infection, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamira J.","family":"Shallom","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2847-7428","authenticated-orcid":true,"given":"Adrian M.","family":"Zelazny","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank","family":"Gupta","sequence":"additional","affiliation":[{"name":"Laboratory of Chronic Airway Infection, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8200-255X","authenticated-orcid":true,"given":"Kenneth N.","family":"Olivier","sequence":"additional","affiliation":[{"name":"Laboratory of Chronic Airway Infection, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207983"},{"key":"e_1_3_2_3_2","unstructured":"Drugbank Online. 2005. Disulfiram. https:\/\/go.drugbank.com\/drugs\/DB00822. Accessed 12 February 2022."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz018"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06445-11"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00898-17"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S299177"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/acmi.0.000154"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2017.10.001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2003.131106"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2450-9_20"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.17226\/12910"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3791\/2079"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049159"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jam.14094"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00539-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00539-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T08:01:12Z","timestamp":1668499272000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00539-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,15]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11,15]]}},"alternative-id":["10.1128\/aac.00539-22"],"URL":"https:\/\/doi.org\/10.1128\/aac.00539-22","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,15]]},"assertion":[{"value":"2022-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00539-22"}}