{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:00:33Z","timestamp":1761580833842},"reference-count":29,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The antibacterial efficacy of gamithromycin administered once 1, 5, or 10 days prior to a challenge infection with\n            <jats:italic>Mannheimia haemolytica<\/jats:italic>\n            serotype A1 was evaluated. Forty calves were randomly allocated on day \u221211, restricted by body weight, to one of three treatment groups given gamithromycin at 6 mg\/kg of body weight 10, 5, or 1 days before challenge or to an untreated control group.\n            <jats:italic>M. haemolytica<\/jats:italic>\n            A1 challenge infections were induced on day 0 by depositing 7.4 \u00d7 10\n            <jats:sup>7<\/jats:sup>\n            CFU at the bifurcation of the main bronchus using a bronchoscope. Clinical observations were made daily from the day of allocation to day 10, when necropsy was scheduled; three calves died or were euthanized\n            <jats:italic>in extremis<\/jats:italic>\n            on welfare grounds prior to scheduled necropsy. At necropsy the lungs were removed, pneumonic lesions were scored, and samples of lung tissue were cultured for\n            <jats:italic>M. haemolytica<\/jats:italic>\n            . The three groups of animals treated with gamithromycin before challenge had significantly lower lung\n            <jats:italic>M. haemolytica<\/jats:italic>\n            counts and fewer clinical signs of respiratory disease than did the saline-treated group. For most of the clinical parameters, the pattern of responses differed significantly (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05) between the gamithromycin-treated groups and the control group. There were no statistically significant differences between groups in the mean lung lesion scores, partly as a result of high individual variability, particularly within the control group. The administration of gamithromycin 1, 5, and 10 days prior to\n            <jats:italic>M. haemolytica<\/jats:italic>\n            A1 challenge resulted in a reduction in bacterial isolation from the lungs and a reduction in the severity of clinical disease.\n          <\/jats:p>","DOI":"10.1128\/aac.00552-10","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T04:14:55Z","timestamp":1289880895000},"page":"831-835","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Determination of the Duration of Antibacterial Efficacy following Administration of Gamithromycin Using a Bovine\n            <i>Mannheimia haemolytica<\/i>\n            Challenge Model"],"prefix":"10.1128","volume":"55","author":[{"given":"A. B.","family":"Forbes","sequence":"first","affiliation":[{"name":"Merial, 29 Avenue Tony Garnier, Lyon 69007, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ramage","sequence":"additional","affiliation":[{"name":"Moredun Scientific Ltd., Pentlands Science Park, Penicuik, Midlothian EH26 0PZ, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sales","sequence":"additional","affiliation":[{"name":"Biomathematics &amp; Statistics Scotland, the King's Buildings, Mayfield Road, Edinburgh EH9 3JZ, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Baggott","sequence":"additional","affiliation":[{"name":"Merial, Sandringham House, Harlow, Essex CM19 5TG, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Donachie","sequence":"additional","affiliation":[{"name":"Moredun Research Institute, Pentlands Science Park, Penicuik, Midlothian EH26 0PZ, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)01262-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2006.10.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.146.19.545"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2527\/2001.7951162x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2004.65.860"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1466252307001417"},{"key":"e_1_3_2_8_2","first-page":"175","volume":"2009","year":"2009","unstructured":"Dezier, C., and A. 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