{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:45:12Z","timestamp":1791726312037,"version":"4.3.4"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Scynexis, Inc."}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,7,16]]},"abstract":"<jats:p>\n            The vaginal environment with candidiasis has a pH of 3.8 to 4.5 and this has a negative effect on the activity of antifungals. Ibrexafungerp was evaluated against 187\n            <jats:italic>Candida<\/jats:italic>\n            isolates, including fluconazole-sensitive and -resistant\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">Candida glabrata<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">Candida krusei<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">Candida parapsilosis<\/jats:named-content>\n            , and\n            <jats:named-content content-type=\"genus-species\">Candida tropicalis<\/jats:named-content>\n            with the media adjusted to pH 7.0 and pH 4.5.\n          <\/jats:p>","DOI":"10.1128\/aac.00562-21","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T13:05:01Z","timestamp":1621256701000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["<i>In Vitro<\/i>\n            pH Activity of Ibrexafungerp against Fluconazole-Susceptible and -Resistant\n            <i>Candida<\/i>\n            Isolates from Women with Vulvovaginal Candidiasis"],"prefix":"10.1128","volume":"65","author":[{"given":"Jack D.","family":"Sobel","sequence":"first","affiliation":[{"name":"Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katyna","family":"Borroto-Esoda","sequence":"additional","affiliation":[{"name":"SCYNEXIS, Inc., Jersey City, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nkechi","family":"Azie","sequence":"additional","affiliation":[{"name":"SCYNEXIS, Inc., Jersey City, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Angulo","sequence":"additional","affiliation":[{"name":"SCYNEXIS, Inc., Jersey City, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Centers for Disease Control and Prevention. 2020. Fungal diseases: vaginal candidiasis. https:\/\/www.cdc.gov\/fungal\/diseases\/candidiasis\/genital\/index.html. Accessed 19 June 2020."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8020144"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy776"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2015.1091805"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof6010027"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0b013e31827307b2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4236\/aid.2013.34035"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof4040121"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2217\/17455057.1.2.253"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9060312"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx008"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05025-11"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000383"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.07.010"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myz083"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.642358"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01961-16"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02119-18"},{"key":"e_1_3_2_20_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard, third edition. CLSI document M27\u2013A4.","author":"Clinical and Laboratory Standards Institute","year":"2017","unstructured":"Clinical and Laboratory Standards Institute. 2017. Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard, third edition. CLSI document M27\u2013A4. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2011.03.016"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7040498"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4441-4443.2004"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00562-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00562-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:03:41Z","timestamp":1645484621000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00562-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,16]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,7,16]]}},"alternative-id":["10.1128\/AAC.00562-21"],"URL":"https:\/\/doi.org\/10.1128\/aac.00562-21","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,16]]},"assertion":[{"value":"2021-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00562-21"}}