{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:49:45Z","timestamp":1790358585582,"version":"4.1.0"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Brucella suis<\/jats:italic>\n            histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues. The growth of this pathogen in minimal medium was inhibited and the multiplication in human macrophages was totally abolished in the presence of the drugs. These effects have been shown to be correlated with the previously described inhibition of\n            <jats:italic>Brucella<\/jats:italic>\n            HDH activity.\n          <\/jats:p>","DOI":"10.1128\/aac.00572-07","type":"journal-article","created":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T00:41:45Z","timestamp":1187052105000},"page":"3752-3755","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Targeting of the\n            <i>Brucella suis<\/i>\n            Virulence Factor Histidinol Dehydrogenase by Histidinol Analogues Results in Inhibition of Intramacrophagic Multiplication of the Pathogen"],"prefix":"10.1128","volume":"51","author":[{"given":"Pascale","family":"Joseph","sequence":"first","affiliation":[{"name":"Centre d'Etudes d'Agents Pathoge\u0300nes et Biotechnologies pour la Sante\u0301 (CPBS) CNRS-UM1-UM2, UMR 5236, Universite\u0301 Montpellier II, 34095 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Rose","family":"Abdo","sequence":"additional","affiliation":[{"name":"Institut des Biomole\u0301cules Max Mousseron (IBMM), CNRS-UM1-UM2, UMR 5247, ENSCM, 34296 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose-Anne","family":"Boigegrain","sequence":"additional","affiliation":[{"name":"Centre d'Etudes d'Agents Pathoge\u0300nes et Biotechnologies pour la Sante\u0301 (CPBS) CNRS-UM1-UM2, UMR 5236, Universite\u0301 Montpellier II, 34095 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Montero","sequence":"additional","affiliation":[{"name":"Institut des Biomole\u0301cules Max Mousseron (IBMM), CNRS-UM1-UM2, UMR 5247, ENSCM, 34296 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Winum","sequence":"additional","affiliation":[{"name":"Institut des Biomole\u0301cules Max Mousseron (IBMM), CNRS-UM1-UM2, UMR 5247, ENSCM, 34296 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ko\u0308hler","sequence":"additional","affiliation":[{"name":"Centre d'Etudes d'Agents Pathoge\u0300nes et Biotechnologies pour la Sante\u0301 (CPBS) CNRS-UM1-UM2, UMR 5236, Universite\u0301 Montpellier II, 34095 Montpellier Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.04.027"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.9.3922-3925.2005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.56.2.174"},{"key":"e_1_3_2_5_2","first-page":"2131","volume":"67","year":"1996","unstructured":"Dancer, J. 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