{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T17:03:07Z","timestamp":1770397387794,"version":"3.49.0"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Consejeria de Salud, Servicio Andaluz de Salud","award":["C-0010\/13"],"award-info":[{"award-number":["C-0010\/13"]}]},{"DOI":"10.13039\/501100004587","name":"MINECO | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14\/01693"],"award-info":[{"award-number":["PI14\/01693"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"MINECO | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD12\/0017\/0029"],"award-info":[{"award-number":["RD12\/0017\/0029"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"MINECO | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CPII13\/00037"],"award-info":[{"award-number":["CPII13\/00037"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002878","name":"Consejer\u00eda de Econom\u00eda, Innovaci\u00f3n, Ciencia y Empleo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["CTS2593"],"award-info":[{"award-number":["CTS2593"]}],"id":[{"id":"10.13039\/501100002878","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>We explored if baseline CD4\/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pretreatment CD4 counts, we observed a lower pretreatment CD4\/CD8 T-cell ratio in immunodiscordant subjects. Furthermore, pretreatment CD4\/CD8 T-cell ratio, but not CD4 counts, correlated with the main immunological alterations observed in immunodiscordants, including increased regulatory T-cell (Treg) frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4\/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV variants. Our results suggest that the CD4\/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance.<\/jats:p>","DOI":"10.1128\/aac.00605-17","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:40:34Z","timestamp":1496191234000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["A Lower Baseline CD4\/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects"],"prefix":"10.1128","volume":"61","author":[{"given":"I.","family":"Rosado-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Laboratory of Immunovirology, Institute of Biomedicine of Seville, IBiS, Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Herrero-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunovirology, Institute of Biomedicine of Seville, IBiS, Virgen del Roc\u00edo University Hospital\/CSIC\/University of Seville, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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