{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:21:40Z","timestamp":1790490100682,"version":"4.1.0"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI111891"],"award-info":[{"award-number":["R01AI111891"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["P30AI50410"],"award-info":[{"award-number":["P30AI50410"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["5P30CA016080-42"],"award-info":[{"award-number":["5P30CA016080-42"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["U54-CA156733"],"award-info":[{"award-number":["U54-CA156733"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["3P30EOS010126-17"],"award-info":[{"award-number":["3P30EOS010126-17"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI149672"],"award-info":[{"award-number":["R01AI149672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI143411"],"award-info":[{"award-number":["R01AI143411"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK119945"],"award-info":[{"award-number":["R01DK119945"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005562","name":"North Carolina Biotechnology Center","doi-asserted-by":"publisher","award":["2015-IDG-1007"],"award-info":[{"award-number":["2015-IDG-1007"]}],"id":[{"id":"10.13039\/100005562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-002704"],"award-info":[{"award-number":["INV-002704"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005496","name":"American Foundation for Pharmaceutical Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005496","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,8,16]]},"abstract":"<jats:p>Although current antiretroviral therapy (ART) has increased life expectancy, a cure for human immunodeficiency virus (HIV) remains elusive due to the persistence of the virus in tissue reservoirs. In the present study, we sought to elucidate the relationship between antiretrovirals (ARVs) and viral expression in the spleen.<\/jats:p>","DOI":"10.1128\/aac.00609-22","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T13:00:57Z","timestamp":1658322057000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates"],"prefix":"10.1128","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2778-3725","authenticated-orcid":true,"given":"Aaron S.","family":"Devanathan","sequence":"first","affiliation":[{"name":"UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole R.","family":"White","sequence":"additional","affiliation":[{"name":"UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yury","family":"Desyaterik","sequence":"additional","affiliation":[{"name":"UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"De la Cruz","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nekorchuk","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health &amp; Science University, Beaverton, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Terry","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health &amp; Science University, Beaverton, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Busman-Sahay","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health &amp; Science University, Beaverton, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Adamson","sequence":"additional","affiliation":[{"name":"University of California at Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Luciw","sequence":"additional","affiliation":[{"name":"University of California at Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Fedoriw","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob D.","family":"Estes","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health &amp; Science University, Beaverton, Oregon, USA"},{"name":"Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health &amp; Science University, Beaverton, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5531-7281","authenticated-orcid":true,"given":"Elias P.","family":"Rosen","sequence":"additional","affiliation":[{"name":"UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela D. M.","family":"Kashuba","sequence":"additional","affiliation":[{"name":"UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA"},{"name":"University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4415\/ANN_11_01_10"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081355"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/387183a0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/527324"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328353f3f1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000688"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1669"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16933"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2017.0254"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav2045"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318249111"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI134815"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01384-20"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aap8758"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2018.1539278"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00019-21"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00674-16"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/01926230600867743"},{"key":"e_1_3_3_20_2","unstructured":"Devanathan AS White NR Desyaterik Y De la Cruz G Nekorchuk M Terry M Busman-Sahay K Adamson L Luciw P Fedoriw Y Estes JD Rosen EP Kashuba ADM. 2021. The spatial relationship between antiretrovirals and cell-associated RT-SHIV RNA in the spleens of nonhuman primates using quantitative imaging analysis abstr 7. Abstr 22nd Int Workshop Clin Pharmacol HIV Hepat Other Antivir Drugs."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.20411\/pai.v1i1.100"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5289.985"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.625"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4411"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02356-09"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01920-18"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414926112"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216413"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.13.5.556-560.2006"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1086\/510852"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1086\/590112"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.259150"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01639-19"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-7-89"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-019-0479-9"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/jms.1180"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-012-0505-9"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00290-16"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02933"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00065-19"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12519"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22984"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-014-8220-y"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.4155\/bio-2019-0035"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.11.4721-4732.2005"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.s2268"},{"key":"e_1_3_3_47_2","volume-title":"Emtriva package insert.","author":"Gilead Sciences, Inc","year":"2018","unstructured":"Gilead Sciences, Inc. 2018. Emtriva package insert. Gilead Sciences, Inc., Foster City, CA."},{"key":"e_1_3_3_48_2","volume-title":"REYATAZ (atazanavir) new drug application, scientific discussion.","author":"European Medicines Agency.","year":"2004","unstructured":"European Medicines Agency. 2004. REYATAZ (atazanavir) new drug application, scientific discussion. European Medicines Agency, London, United Kingdom."},{"key":"e_1_3_3_49_2","volume-title":"Viread package insert.","author":"Gilead Sciences, Inc","year":"2019","unstructured":"Gilead Sciences, Inc. 2019. Viread package insert. Gilead Sciences, Inc., Foster City, CA."},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04952-14"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-017-1809-6"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00609-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00609-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T13:05:19Z","timestamp":1660655119000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00609-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,16]]}},"alternative-id":["10.1128\/aac.00609-22"],"URL":"https:\/\/doi.org\/10.1128\/aac.00609-22","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,16]]},"assertion":[{"value":"2022-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00609-22"}}