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We present one of the first reports of small-colony variant (SCV) emergence of\n                    <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n                    , taken from a patient under aminoglycosides for a persistent burn wound infection. We confirm the causative role of a single\n                    <jats:italic>ispA<\/jats:italic>\n                    mutation in SCV emergence and increased aminoglycoside resistance. IspA is involved in the synthesis of ubiquinone, providing a possible link between electron transport and SCV formation in\n                    <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n                    .\n                  <\/jats:p>","DOI":"10.1128\/aac.00621-22","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T09:00:44Z","timestamp":1657011644000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Mutation to\n                    <i>ispA<\/i>\n                    Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance"],"prefix":"10.1128","volume":"66","author":[{"given":"Melissa","family":"Pitton","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"},{"name":"Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Oberhaensli","sequence":"additional","affiliation":[{"name":"Interfaculty Bioinformatics Unit, University of Bern, Bern Switzerland"},{"name":"SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Appiah","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Pagani","sequence":"additional","affiliation":[{"name":"Service of Intensive Care Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3813-1199","authenticated-orcid":true,"given":"Anne","family":"Fournier","sequence":"additional","affiliation":[{"name":"Service of Pharmacy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan M.","family":"Jakob","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9443-6101","authenticated-orcid":true,"given":"Yok-Ai","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2020.346"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721270115"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.9.3838-3846.1997"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2010.08.008"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009112"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1384"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/514706"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/416740a"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002760"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000262"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01178-17"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.15.4706-4712.1997"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/374642"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(99)00170-3"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2016.05.011"},{"key":"e_1_3_3_17_2","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. 2022. 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