{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:11:27Z","timestamp":1791133887751,"version":"4.1.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Highly active antiretroviral therapy (HAART) of human immunodeficiency virus-infected patients is associated with adverse effects, such as lipodystrophy and hyperlipidemia. The lipodystrophic syndrome is characterized by a peripheral lipoatrophy and\/or fat accumulation in the abdomen and neck. In order to get insights into the physiopathological mechanisms underlying this syndrome, we treated mice with protease inhibitors (PIs) over a long period of time. Although atazanavir-treated mice presented the same circulating triglyceride concentration as control mice, lopinavir-ritonavir-treated mice rapidly became hypertriglyceridemic, with triglyceride levels of 200 mg\/dl, whereas control and atazanavir-treated animals had triglyceride levels of 80 mg\/dl. These results obtained with mice reproduce the metabolic disorder observed in humans. White adipose tissue (WAT) was analyzed after 8 weeks of treatment. Compared to the control or atazanavir treatment, lopinavir-ritonavir treatment induced a significant 25% weight reduction in the peripheral inguinal WAT depot. By contrast, the profound epididymal WAT depot was not affected. This effect was associated with a 5.5-fold increase in\n            <jats:italic>SREBP-1c<\/jats:italic>\n            gene expression only in the inguinal depot. Our results demonstrate that the long-term treatment of mice with PIs constitutes an interesting experimental model with which some aspects of the lipoatrophy induced by HAART in humans may be studied.\n          <\/jats:p>","DOI":"10.1128\/aac.00625-06","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T19:39:16Z","timestamp":1164224356000},"page":"3998-4004","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Long-Term Treatment with Lopinavir-Ritonavir Induces a Reduction in Peripheral Adipose Depots in Mice"],"prefix":"10.1128","volume":"50","author":[{"given":"Matthieu","family":"Prot","sequence":"first","affiliation":[{"name":"INSERM, U568, Nice, F-06107, France"},{"name":"Universite\u0301 de Nice Sophia-Antipolis, Faculte\u0301 de Me\u0301decine, av de Valombrose, Nice, F-06107, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Heripret","sequence":"additional","affiliation":[{"name":"INSERM, U568, Nice, F-06107, France"},{"name":"Universite\u0301 de Nice Sophia-Antipolis, Faculte\u0301 de Me\u0301decine, av de Valombrose, Nice, F-06107, France"},{"name":"CHU de Nice, Service d'Infectiologie Ho\u0302pital l'Archet-1, route de saint Antoine de Ginestie\u0300re, 06202 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Cardot-Leccia","sequence":"additional","affiliation":[{"name":"CHU de Nice, Laboratoire Central d'Anatomie Pathologique, Ho\u0302pital Pasteur, 20 av de la voie romaine, BP 69, 06002 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Perrin","sequence":"additional","affiliation":[{"name":"CHU de Nice, Laboratoire Central d'Anatomie Pathologique, Ho\u0302pital Pasteur, 20 av de la voie romaine, BP 69, 06002 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Aouadi","sequence":"additional","affiliation":[{"name":"INSERM, U568, Nice, F-06107, France"},{"name":"Universite\u0301 de Nice Sophia-Antipolis, Faculte\u0301 de Me\u0301decine, av de Valombrose, Nice, F-06107, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Lavrut","sequence":"additional","affiliation":[{"name":"CHU de Nice, Laboratoire de Pharmacologie-Toxicologie, Ho\u0302pital Pasteur, 20 av de la voie romaine, BP 69, 06002 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolphe","family":"Garraffo","sequence":"additional","affiliation":[{"name":"CHU de Nice, Laboratoire de Pharmacologie-Toxicologie, Ho\u0302pital Pasteur, 20 av de la voie romaine, BP 69, 06002 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Dellamonica","sequence":"additional","affiliation":[{"name":"CHU de Nice, Service d'Infectiologie Ho\u0302pital l'Archet-1, route de saint Antoine de Ginestie\u0300re, 06202 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Durant","sequence":"additional","affiliation":[{"name":"CHU de Nice, Service d'Infectiologie Ho\u0302pital l'Archet-1, route de saint Antoine de Ginestie\u0300re, 06202 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Le Marchand-Brustel","sequence":"additional","affiliation":[{"name":"INSERM, U568, Nice, F-06107, France"},{"name":"Universite\u0301 de Nice Sophia-Antipolis, Faculte\u0301 de Me\u0301decine, av de Valombrose, Nice, F-06107, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Bine\u0301truy","sequence":"additional","affiliation":[{"name":"INSERM, U568, Nice, F-06107, France"},{"name":"Universite\u0301 de Nice Sophia-Antipolis, Faculte\u0301 de Me\u0301decine, av de Valombrose, Nice, F-06107, France"},{"name":"INSERM, U626, Marseille, F-13385, France"},{"name":"Universite\u0301 de la Me\u0301diterrane\u0301e, Faculte\u0301 de Me\u0301decine La Timone, 26 bd J Moulin, 13385 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1172\/JCI119870","volume":"100","year":"1997","unstructured":"Adams, M., C. 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