{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T10:55:28Z","timestamp":1782039328381,"version":"3.54.5"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Although extended-spectrum-\u03b2-lactamase (ESBL)-producing aeromonads have been increasingly reported in recent years, most of them were isolates from case reports or environmental isolates. To investigate the prevalence of ESBL producers among\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aeromonas<\/jats:named-content>\n            blood isolates and the genes encoding ESBLs, consecutive nonduplicate\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aeromonas<\/jats:named-content>\n            blood isolates collected at a medical center in southern Taiwan from March 2004 to December 2008 were studied. The ESBL phenotypes were examined by clavulanate combination disk test and the cefepime-clavulanate ESBL Etest. The presence of ESBL-encoding genes, including\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>TEM<\/jats:sub>\n            ,\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>PER<\/jats:sub>\n            ,\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M<\/jats:sub>\n            , and\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>SHV<\/jats:sub>\n            genes, was evaluated by PCR and sequence analysis. The results showed that 4 (2.6%) of 156\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aeromonas<\/jats:named-content>\n            blood isolates, 1\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aeromonas hydrophila<\/jats:named-content>\n            isolate and 3\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aeromonas caviae<\/jats:named-content>\n            isolates, expressed an ESBL-producing phenotype. The ESBL gene in two\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. caviae<\/jats:named-content>\n            isolates was\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>PER-3<\/jats:sub>\n            , which was located in both chromosomes and plasmids, as demonstrated by Southern hybridization. Of four patients with ESBL-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aeromonas<\/jats:named-content>\n            bacteremia, two presented with catheter-related phlebitis and the other two with primary bacteremia. Three patients had been treated with initial noncarbapenem \u03b2-lactams for 5 to 10 days, and all survived. In conclusion, ESBL producers exist among\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aeromonas<\/jats:named-content>\n            blood isolates, and clinical suspicion of ESBL production should be raised in treating infections due to cefotaxime-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aeromonas<\/jats:named-content>\n            isolates.\n          <\/jats:p>","DOI":"10.1128\/aac.00634-11","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T04:10:31Z","timestamp":1317701431000},"page":"5813-5818","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":57,"title":["Bacteremia Due to Extended-Spectrum-\u03b2-Lactamase-Producing Aeromonas spp. at a Medical Center in Southern Taiwan"],"prefix":"10.1128","volume":"55","author":[{"given":"Chi-Jung","family":"Wu","sequence":"first","affiliation":[{"name":"Departments of Graduate Institute of Clinical Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"},{"name":"Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"},{"name":"National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Ching","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan"},{"name":"Department of Internal Medicine, Chi Mei Medical Center, Liou Ying, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Feng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chi","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Graduate Institute of Clinical Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"},{"name":"Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"},{"name":"Center for Infection Control, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Chun","family":"Lee","sequence":"additional","affiliation":[{"name":"Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"},{"name":"Center for Infection Control, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Yao","family":"Lee","sequence":"additional","affiliation":[{"name":"Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"},{"name":"Center for Infection Control, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ming","family":"Chang","sequence":"additional","affiliation":[{"name":"Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"},{"name":"Center for Infection Control, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Departments of Graduate Institute of Clinical Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"},{"name":"Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tzu","family":"Lin","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jou","family":"Yan","sequence":"additional","affiliation":[{"name":"Pathology, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[{"name":"Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"},{"name":"Center for Infection Control, National Cheng Kung University Medical College and Hospital, Tainan, 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