{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:22:06Z","timestamp":1790338926292,"version":"4.1.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>High dosages of ceftriaxone are used to treat central nervous system (CNS) infections. Dosage adaptation according to the glomerular filtration rate is currently not recommended. Ceftriaxone pharmacokinetics (PK) was investigated by a population approach in patients enrolled in a French multicenter prospective cohort study who received high-dose ceftriaxone for CNS infection as recommended by French guidelines (75 to 100\u2009mg\/kg of body weight\/day without an upper limit).<\/jats:p>","DOI":"10.1128\/aac.00634-19","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T12:03:43Z","timestamp":1561464223000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["High-Dose Ceftriaxone for Bacterial Meningitis and Optimization of Administration Scheme Based on Nomogram"],"prefix":"10.1128","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1232-5761","authenticated-orcid":false,"given":"Matthieu","family":"Gr\u00e9goire","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Department, CHU Nantes, Nantes, France"},{"name":"UMR INSERM 1235, Enteric Nervous System in Gut and Brain Disorders, University of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Dailly","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, CHU Nantes, Nantes, France"},{"name":"EE 1701 MiHAR, University of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Le Turnier","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, CHU Nantes and CIC 1413, INSERM, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Garot","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, CHU Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Guimard","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Emergency Department, Centre Hospitalier de La Roche sur Yon, La Roche sur Yon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Bernard","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, CHU Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Tattevin","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, CHU Rennes, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves-Marie","family":"Vandamme","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, CHU Angers, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Hoff","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Anaesthesia and Critical Care Department, Centre Hospitalier de Saint Nazaire, Saint Nazaire, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Lemaitre","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, CHU Rennes, Rennes, France"},{"name":"INSERM, CIC-P 1414 Clinical Investigation Center, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Cl\u00e9mence","family":"Verdier","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, CHU Rennes, Rennes, France"},{"name":"INSERM, CIC-P 1414 Clinical Investigation Center, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Deslandes","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, CHU Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2550-9255","authenticated-orcid":false,"given":"Ronan","family":"Bellouard","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, CHU Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"S\u00e9bille","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Research Board, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Chiffoleau","sequence":"additional","affiliation":[{"name":"Pharmacovigilance, Research Board, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Boutoille","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, CHU Nantes and CIC 1413, INSERM, Nantes, France"},{"name":"EA 3826 Th\u00e9rapeutiques Cliniques et Exp\u00e9rimentales des Infections, University of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Navas","sequence":"additional","affiliation":[{"name":"EA 3826 Th\u00e9rapeutiques Cliniques et Exp\u00e9rimentales des Infections, University of Nantes, Nantes, France"},{"name":"Pharmacy Department, CHU Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Asseray","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, CHU Nantes and CIC 1413, INSERM, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2008.12.001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.01.007"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/425368"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200645050-00004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2010.01179.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03191159"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.04005.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2007.03.015"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-13-124"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198631030-00004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.90"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky071"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12636"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01711224"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-015-0454-2"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-012-0018-5"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.09.021"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.23.1.46"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/14.4.427"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz047"},{"key":"e_1_3_2_22_2","unstructured":"EUCAST. 2019. MIC and zone distributions and ECOFFs. http:\/\/www.eucast.org\/mic_distributions_and_ecoffs\/."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp048246"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu027"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01586-06"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx427"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl529"},{"key":"e_1_3_2_28_2","volume-title":"Optimisation du traitement par b\u00eata-lactamines","author":"Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Anesth\u00e9sie et de R\u00e9animation","year":"2018","unstructured":"Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Anesth\u00e9sie et de R\u00e9animation. 2018. Optimisation du traitement par b\u00eata-lactamines. Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Anesth\u00e9sie et de R\u00e9animation, Paris, France. https:\/\/sfar.org\/optimisation-du-traitement-par-beta-lactamines-chez-le-patient-de-soins-critiques\/."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky553"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00533-11"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2012.09.016"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e31825c4ba6"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-011-9255-z"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.37.7.1518"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00634-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00634-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:25:11Z","timestamp":1645478711000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00634-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1128\/AAC.00634-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.00634-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"2019-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00634-19"}}