{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:16:18Z","timestamp":1793661378532,"version":"4.5.1"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      We evaluated cefiderocol activity against carbapenem-resistant\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      (CRPA) and carbapenem-resistant\n                      <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                      (CRAB), characterized the \u03b2-lactamase gene profiles of cefiderocol-nonsusceptible CRPA by metallo-\u03b2-lactamase (MBL) subtype, and assessed cross-resistance with comparator agents. Cefiderocol minimum inhibitory concentrations (MICs) for 890 CRPA and 1,063 CRAB isolates from the 2024 Antimicrobial Testing Leadership and Surveillance (ATLAS) program were determined by broth microdilution using iron-depleted cation-adjusted Mueller-Hinton broth. Cefiderocol nonsusceptibility was defined as MIC \u2265 8 mg\/L per CLSI (intermediate + resistant). DTRPA was defined as nonsusceptible to all anti-pseudomonal \u03b2-lactams and fluoroquinolones; DTRAB was defined as nonsusceptible to carbapenems, ampicillin-sulbactam, and fluoroquinolones, reflecting species-specific susceptibility panels. CRPA isolates underwent molecular screening for\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM<\/jats:sub>\n                      ,\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>VIM<\/jats:sub>\n                      ,\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>IMP<\/jats:sub>\n                      , serine carbapenemase, and ESBL genes; genotype data were not available for\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      . Cefiderocol susceptibility was 93.9% for CRPA and 88.5% for CRAB, respectively (nonsusceptibility 6.1% and 11.5%, respectively; OR = 2.01,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001); nonsusceptibility among DTRPA and DTRAB was 8.1% and 11.7%, respectively. Among 54 cefiderocol-nonsusceptible CRPA, 41 (76%) harbored no detectable carbapenemase gene. Nonsusceptibility among MBL-positive CRPA was exclusively attributable to\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM<\/jats:sub>\n                      producers (27.7%, 13\/47);\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>VIM<\/jats:sub>\n                      -positive (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 68) and\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>IMP<\/jats:sub>\n                      -positive (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 21) isolates were uniformly susceptible. Among cefiderocol-nonsusceptible CRPA, 98.1% were co-resistant to ceftazidime-avibactam and 96.3% to ceftolozane-tazobactam.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00634-26","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:57:58Z","timestamp":1783951078000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Cefiderocol nonsusceptibility among carbapenem-resistant\n                    <i>Pseudomonas aeruginosa<\/i>\n                    and\n                    <i>Acinetobacter baumannii<\/i>\n                    : data from the 2024 Antimicrobial Testing Leadership and Surveillance (ATLAS) program"],"prefix":"10.1128","volume":"70","author":[{"given":"Po-Wei","family":"Chiu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zx3rq17","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine, National Cheng Kung University Hospital","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9465-8692","authenticated-orcid":false,"given":"Jiun-Ling","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zx3rq17","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine, National Cheng Kung University Hospital","place":["Tainan, Taiwan"]},{"id":[{"id":"https:\/\/ror.org\/01b8kcc49","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicine, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Chung","family":"Hsueh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital","place":["Taipei City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Yao","family":"Lee","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zx3rq17","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine, National Cheng Kung University Hospital","place":["Tainan, Taiwan"]},{"id":[{"id":"https:\/\/ror.org\/01b8kcc49","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicine, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]},{"id":[{"id":"https:\/\/ror.org\/04zx3rq17","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Infection Control, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tsung","family":"Huang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine","place":["Taipei City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04zx3rq17","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Internal Medicine, National Cheng Kung University Hospital","place":["Tainan, Taiwan"]},{"id":[{"id":"https:\/\/ror.org\/01b8kcc49","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicine, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7502-9225","authenticated-orcid":true,"given":"Po-Ren","family":"Hsueh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine","place":["Taipei City, Taiwan"]},{"id":[{"id":"https:\/\/ror.org\/0368s4g32","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, School of Medicine, China Medical University","place":["Taichung, Taiwan"]},{"id":[{"id":"https:\/\/ror.org\/0368s4g32","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Laboratory Medicine, China Medical University Hospital, School of Medicine, China Medical University","place":["Taichung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","unstructured":"World Health Organization. 2024. 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