{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:00:04Z","timestamp":1785420004973,"version":"3.56.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,8,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Wong-So and colleagues describe a case of post-neurosurgical\n                      <jats:italic toggle=\"yes\">Stenotrophomonas maltophilia<\/jats:italic>\n                      meningitis successfully managed with ceftazidime-avibactam and aztreonam. While aztreonam is stable against L1 metallo-\u03b2-lactamase-mediated hydrolysis, it remains susceptible to L2 serine \u03b2-lactamases, which are effectively inhibited by avibactam, restoring aztreonam\u2019s bactericidal activity. Simultaneous peak and trough levels in cerebrospinal fluid (CSF) and plasma demonstrated favorable CSF-to-plasma ratios for both aztreonam and avibactam. This case highlights aztreonam-avibactam as a rational therapeutic strategy for\n                      <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                      meningitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00640-25","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T13:42:04Z","timestamp":1752068524000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Case Commentary: Overcoming intrinsic resistance\u2014the successful use of aztreonam and avibactam for\n                    <i>Stenotrophomonas maltophilia<\/i>\n                    meningitis"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5861-3999","authenticated-orcid":true,"given":"Alice J.","family":"Hsu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05cb1k848","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacy, The Johns Hopkins Hospital","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-6324","authenticated-orcid":true,"given":"Pranita D.","family":"Tamma","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatrics, Division of Pediatric Infectious Diseases, The Johns Hopkins University School of Medicine","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00172-25"},{"key":"e_1_3_2_3_2","unstructured":"AbbVie Inc. Aztreonam and avibactam: product information. Available from: https:\/\/www.rxabbvie.com\/pdf\/emblaveo_pi.pdf. Retrieved 19 May 2025."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa778"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00793-21"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00124-25"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00297-20"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00264-16"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idnow.2021.01.014"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000857"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.17290"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.06.089"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2023.08.029"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00618-22"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2021.106395"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad174"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1410"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-022-05006-3"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004051"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30796-9"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaf071"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13010058"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00007-10"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(85)90261-x"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00640-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00640-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:39:07Z","timestamp":1773178747000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00640-25"}},"subtitle":[],"editor":[{"given":"Cesar A.","family":"Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,6]]}},"alternative-id":["10.1128\/aac.00640-25"],"URL":"https:\/\/doi.org\/10.1128\/aac.00640-25","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,6]]},"assertion":[{"value":"2025-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00640-25"}}