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Here, we aimed to identify the target of a novel class of CHIKV inhibitors, i.e., the CHVB series. CHVB compounds inhibit the\n            <jats:italic>in vitro<\/jats:italic>\n            replication of CHIKV isolates with 50% effective concentrations in the low-micromolar range. A CHVB-resistant variant (CHVB\n            <jats:sup>res<\/jats:sup>\n            ) was selected that carried two mutations in the gene encoding nsP1 (responsible for viral RNA capping), one mutation in nsP2, and one mutation in nsP3.\n          <\/jats:p>","DOI":"10.1128\/aac.00649-20","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T17:21:59Z","timestamp":1588008119000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery"],"prefix":"10.1128","volume":"64","author":[{"given":"Rana","family":"Abdelnabi","sequence":"first","affiliation":[{"name":"KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, 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