{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:52:52Z","timestamp":1791251572422,"version":"4.1.0"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Members of the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Arenaviridae<\/jats:named-content>\n            family are a threat to public health and can cause meningitis and hemorrhagic fever, and yet treatment options remain limited by a lack of effective antivirals. In this study, we found that peptide-conjugated phosphorodiamidate morpholino oligomers (PPMO) complementary to viral genomic RNA were effective in reducing arenavirus replication in cell cultures and\n            <jats:italic>in vivo<\/jats:italic>\n            . PPMO complementary to the Jun\u00edn virus genome were designed to interfere with viral RNA synthesis or translation or both. However, only PPMO designed to potentially interfere with translation were effective in reducing virus replication. PPMO complementary to sequences that are highly conserved across the arenaviruses and located at the 5\u2032 termini of both genomic segments were effective against Jun\u00edn virus, Tacaribe virus, Pichinde virus, and lymphocytic choriomeningitis virus (LCMV)-infected cell cultures and suppressed viral titers in the livers of LCMV-infected mice. These results suggest that arenavirus 5\u2032 genomic termini represent promising targets for pan-arenavirus antiviral therapeutic development.\n          <\/jats:p>","DOI":"10.1128\/aac.00650-11","type":"journal-article","created":{"date-parts":[[2011,8,9]],"date-time":"2011-08-09T06:30:16Z","timestamp":1312871416000},"page":"4631-4638","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Development of Peptide-Conjugated Morpholino Oligomers as Pan-Arenavirus Inhibitors"],"prefix":"10.1128","volume":"55","author":[{"given":"Benjamin W.","family":"Neuman","sequence":"first","affiliation":[{"name":"University of Reading, Reading RG6 6AJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia H.","family":"Bederka","sequence":"additional","affiliation":[{"name":"The University of California, Irvine, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Stein","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joey P. 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