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We elucidate expression profiles of superoxide dismutase (SOD)- and catalase (CAT)-encoding genes, enzymatic activities of SODs, and superoxide anion production and signaling pathways involved in the oxidative stress response (OSR) in ATS and ATR strains under AmB treatment conditions. We show that ATR strains possess almost doubled basal SOD activity compared to that of ATS strains and that ATR strains exhibit an enhanced OSR, with significantly higher\n                    <jats:italic>sod2<\/jats:italic>\n                    mRNA levels and significantly increased\n                    <jats:italic>cat<\/jats:italic>\n                    transcripts in ATR strains upon AmB treatment. In particular, inhibition of SOD and CAT proteins renders resistant isolates considerably susceptible to the drug\n                    <jats:italic>in vitro<\/jats:italic>\n                    . In conclusion, this study shows that SODs and CATs are crucial for AmB resistance in\n                    <jats:named-content content-type=\"genus-species\">A. terreus<\/jats:named-content>\n                    and that targeting the OSR might offer new treatment perspectives for resistant species.\n                  <\/jats:p>","DOI":"10.1128\/aac.00670-17","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T20:20:23Z","timestamp":1500927623000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance"],"prefix":"10.1128","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6909-7005","authenticated-orcid":false,"given":"Emina","family":"Jukic","sequence":"first","affiliation":[{"name":"Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, 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