{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:02:51Z","timestamp":1761217371889},"reference-count":23,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Acute invasive pulmonary aspergillosis is a rapidly progressive and frequently lethal infection. Relatively little is known about early events in the pathogenesis and relationship between the cell wall biomarkers galactomannan and (1\u21923)-\u03b2-\n            <jats:sc>d<\/jats:sc>\n            -glucan. The consequences of delayed antifungal therapy are also poorly defined. A persistently neutropenic rabbit model of invasive pulmonary aspergillosis was used to describe the histopathology of early invasive pulmonary aspergillosis and the kinetics of galactomannan and (1\u21923)-\u03b2-\n            <jats:sc>d<\/jats:sc>\n            -glucan. The time course of both molecules was mathematically modeled by using a population methodology, and Monte Carlo simulations were performed. The effect of progressive delay in the administration of amphotericin B deoxycholate 1 mg\/kg at 24, 48, 72, and 96 h postinoculation on fungal burden, lung weight, pulmonary infarct score, and survival was determined. Histopathology showed phagocytosis of conidia by pulmonary alveolar macrophages at 4 h postinoculation. At 12 to 24 h, there was a progressive focal inflammatory response with conidial germination and hyphal extension. Subsequently, hyphae invaded into the contiguous lung. Galactomannan and (1\u21923)-\u03b2-\n            <jats:sc>d<\/jats:sc>\n            -glucan had similar trajectories, and both exhibited considerable interindividual variability, which was reflected in Monte Carlo simulations. Concentrations of both molecules began to rise &lt;24 h postinoculation before pulmonary hemorrhagic infarction was present. Delays of 72 and 96 h in the administration of amphotericin B resulted in fungal burdens and lung weights that were indistinguishable from those of controls, respectively. Galactomannan and (1\u21923)-\u03b2-\n            <jats:sc>d<\/jats:sc>\n            -glucan have similar kinetics and are comparable biomarkers of early invasive pulmonary aspergillosis. Antifungal treatment at \u226548 h postinoculation is associated with suboptimal therapeutic outcomes.\n          <\/jats:p>","DOI":"10.1128\/aac.00673-10","type":"journal-article","created":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T00:29:48Z","timestamp":1282004988000},"page":"4879-4886","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":60,"title":["The Initial 96 Hours of Invasive Pulmonary Aspergillosis: Histopathology, Comparative Kinetics of Galactomannan and (1\u21923)-\u03b2-\n            <scp>d<\/scp>\n            -Glucan, and Consequences of Delayed Antifungal Therapy"],"prefix":"10.1128","volume":"54","author":[{"given":"William W.","family":"Hope","sequence":"first","affiliation":[{"name":"The University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom"},{"name":"Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidmantas","family":"Petraitis","sequence":"additional","affiliation":[{"name":"Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland"},{"name":"Laboratory Animal Sciences Program, SAIC-Frederick, Inc., Frederick, Maryland"},{"name":"Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Weill Cornell Medical College of Cornell University, New York City, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruta","family":"Petraitiene","sequence":"additional","affiliation":[{"name":"Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland"},{"name":"Laboratory Animal Sciences Program, SAIC-Frederick, Inc., Frederick, Maryland"},{"name":"Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Weill Cornell Medical College of Cornell University, New York City, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamarra","family":"Aghamolla","sequence":"additional","affiliation":[{"name":"Laboratory Animal Sciences Program, SAIC-Frederick, Inc., Frederick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Bacher","sequence":"additional","affiliation":[{"name":"Division of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland"},{"name":"Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Weill Cornell Medical College of Cornell University, New York City, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"321","volume":"53","year":"2010","unstructured":"Antachopoulos, C., J. P. Demchok, E. Roilides, and T. J. Walsh. 2010. Fungal biomass is a key factor affecting polymorphonuclear leukocyte-induced hyphal damage of filamentous fungi. Mycoses53:321-328.","journal-title":"Mycoses"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.5.1878-1880.2006"},{"key":"e_1_3_2_4_2","unstructured":"Approved standard M38-A. 2002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/597395"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061094"},{"key":"e_1_3_2_7_2","unstructured":"ADAPT II: a program for simulation identification and optimal experimental design: user manual. 1997"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/169.2.356"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/504810"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00241-06"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802510232"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00601-06"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/510535"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00369-06"},{"key":"e_1_3_2_15_2","first-page":"389","year":"2001","unstructured":"Leary, R., R. Jelliffe, A. Schumitzky, and M. van Guilder. 2001. An adaptive grid, non-parametric approach to pharmacokinetic and dynamic (PK\/PD) models, p. 389-394. Proceedings of the Fourteenth IEEE Computer Society, Bethesda, MD.","journal-title":"Proceedings of the Fourteenth IEEE Computer Society, Bethesda, MD."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.12.4911-4914.2004"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.9.3640-3645.2005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/432470"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.857-869.2001"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/375420"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1974-1976.2002"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01647-09"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01425-07"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22863"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00673-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00673-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:15:21Z","timestamp":1645456521000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00673-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1128\/AAC.00673-10"],"URL":"https:\/\/doi.org\/10.1128\/aac.00673-10","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"type":"print","value":"0066-4804"},{"type":"electronic","value":"1098-6596"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"2010-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}