{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:45:51Z","timestamp":1790837151584,"version":"4.1.0"},"reference-count":47,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100010418","name":"MOD | Defence Science and Technology Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,10,18]]},"abstract":"<jats:p>\n                    Q fever, caused by the intracellular pathogen\n                    <jats:named-content content-type=\"genus-species\">Coxiella burnetii<\/jats:named-content>\n                    , is traditionally treated using tetracycline antibiotics, such as doxycycline. Doxycycline is often poorly tolerated, and antibiotic-resistant strains have been isolated.\n                  <\/jats:p>","DOI":"10.1128\/aac.00673-21","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T16:27:10Z","timestamp":1628526430000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of the Efficacy of Doxycycline, Ciprofloxacin, Levofloxacin, and Co-trimoxazole Using\n                    <i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>\n                    Models of Q Fever"],"prefix":"10.1128","volume":"65","author":[{"given":"K. A.","family":"Clay","sequence":"first","affiliation":[{"name":"Academic Department, Royal Centre for Defence Medicine (Academia and Research), Birmingham, United Kingdom"},{"name":"CBR Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7066-4767","authenticated-orcid":true,"given":"M. G.","family":"Hartley","sequence":"additional","affiliation":[{"name":"CBR Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"CBR Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9078-6734","authenticated-orcid":true,"given":"K. R.","family":"Bewley","sequence":"additional","affiliation":[{"name":"Public Health England, Porton Down, Salisbury, Wiltshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Godwin","sequence":"additional","affiliation":[{"name":"Public Health England, Porton Down, Salisbury, Wiltshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Rayner","sequence":"additional","affiliation":[{"name":"Public Health England, Porton Down, Salisbury, Wiltshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Vipond","sequence":"additional","affiliation":[{"name":"Public Health England, Porton Down, Salisbury, Wiltshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Academic Department, Royal Centre for Defence Medicine (Academia and Research), Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. P.","family":"Atkins","sequence":"additional","affiliation":[{"name":"CBR Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, United Kingdom"},{"name":"College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. H.","family":"Norville","sequence":"additional","affiliation":[{"name":"CBR Division, Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.2807\/ese.17.03.20058-en"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-010-0052-x"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03221-13"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68266-4"},{"key":"e_1_3_1_6_2","first-page":"R128","article-title":"Epidemiological features of Coxiella burnetii infection in England and Wales: 1984 to 1994","volume":"6","author":"Pebody RG","year":"1996","unstructured":"Pebody RG, Wall PG, Ryan MJ, Fairley C. 1996. Epidemiological features of Coxiella burnetii infection in England and Wales: 1984 to 1994. Commun Dis Rep CDR Rev 6:R128\u201332.","journal-title":"Commun Dis Rep CDR Rev"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.10.048"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jramc-157-02-05"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.1962.11.3.184"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.2.167"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-200209000-00001"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2011.00876.x"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.08.006"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2013.840534"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54556-6"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.72.2.235-241.1956"},{"key":"e_1_3_1_17_2","first-page":"469","article-title":"Animal models of Q fever (Coxiella burnetii)","volume":"63","author":"Bewley KR","year":"2013","unstructured":"Bewley KR. 2013. Animal models of Q fever (Coxiella burnetii). Comp Med 63:469\u2013476.","journal-title":"Comp Med"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.077230-0"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00267.x"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/600122"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/43.3.345"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl224"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2003.07.007"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00172"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/39.6.725"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.10.2070"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.11.3276-3278.2001"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008668"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00594-07"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4488"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.1.301-302.2001"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.7.1079"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.05.011"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1086\/520661"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.2807\/ese.18.24.20504-en"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.11.001"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.12.009"},{"key":"e_1_3_1_38_2","first-page":"98","article-title":"Studies on Q fever in man","volume":"69","author":"Benenson AS","year":"1956","unstructured":"Benenson AS, Tigertt WD. 1956. Studies on Q fever in man. Trans Assoc Am Physicians 69:98\u2013104.","journal-title":"Trans Assoc Am Physicians"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01552"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03443-14"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-359"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.6.701"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.10.025"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-005-8209-8"},{"key":"e_1_3_1_45_2","first-page":"79","article-title":"Immunomodulatory effects of levofloxacin on patients with pneumonia in Assiut University hospitals","volume":"22","author":"Badari MS","year":"2015","unstructured":"Badari MS, Elgendy SG, Mohamed AS, Hassan AT. 2015. Immunomodulatory effects of levofloxacin on patients with pneumonia in Assiut University hospitals. Egypt J Immunol 22:79\u201385.","journal-title":"Egypt J Immunol"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2018.02.004"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.3815-3821.2000"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1947.150.1.70"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00673-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00673-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T18:38:12Z","timestamp":1645468692000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00673-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,18]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,10,18]]}},"alternative-id":["10.1128\/AAC.00673-21"],"URL":"https:\/\/doi.org\/10.1128\/aac.00673-21","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,18]]},"assertion":[{"value":"2021-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00673-21"}}