{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:53:12Z","timestamp":1790077992246,"version":"4.0.1"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Emerging antimicrobial resistance in members of the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Bacteroides fragilis<\/jats:named-content>\n            group is a concern in clinical medicine. Although metronidazole and carbapenem resistance have been reported in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Bacteroides thetaiotaomicron<\/jats:named-content>\n            , a member of the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. fragilis<\/jats:named-content>\n            group, they have not, to the best of our knowledge, been reported together in the same\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. thetaiotaomicron<\/jats:named-content>\n            isolate. Herein, we report isolation of piperacillin-tazobactam-, metronidazole-, clindamycin-, ertapenem-, and meropenem-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. thetaiotaomicron<\/jats:named-content>\n            from a patient with postoperative intra-abdominal abscess and empyema. Whole-genome sequencing demonstrated the presence of\n            <jats:italic>nimD<\/jats:italic>\n            with at least a portion of IS\n            <jats:italic>1169<\/jats:italic>\n            upstream, a second putative\n            <jats:italic>nim<\/jats:italic>\n            gene, two \u03b2-lactamase genes (one of which has not been previously reported), two\n            <jats:italic>tetX<\/jats:italic>\n            genes,\n            <jats:italic>tetQ<\/jats:italic>\n            ,\n            <jats:italic>ermF<\/jats:italic>\n            , two\n            <jats:italic>cat<\/jats:italic>\n            genes, and a number of efflux pumps. This report highlights emerging antimicrobial resistance in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. thetaiotaomicron<\/jats:named-content>\n            and the importance of identification and antimicrobial susceptibility testing of selected anaerobic bacteria.\n          <\/jats:p>","DOI":"10.1128\/aac.00677-15","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T01:51:20Z","timestamp":1430790680000},"page":"4157-4161","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Metronidazole- and Carbapenem-Resistant Bacteroides thetaiotaomicron Isolated in Rochester, Minnesota, in 2014"],"prefix":"10.1128","volume":"59","author":[{"given":"Sapna P.","family":"Sadarangani","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0282-4217","authenticated-orcid":false,"given":"Patricio R.","family":"Jeraldo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA"},{"name":"Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reeti","family":"Khare","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA"},{"name":"Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01620.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.5578\/mb.5064"},{"key":"e_1_3_2_4_2","volume-title":"CLSI M100-S25","author":"Clinical and Laboratory Standards Institute","year":"2015","unstructured":"Clinical and Laboratory Standards Institute. 2015. 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