{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:20:24Z","timestamp":1791390024067,"version":"4.3.3"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI169066"],"award-info":[{"award-number":["R01 AI169066"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,9,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The fungal pathogen\n                      <jats:italic toggle=\"yes\">Candida auris<\/jats:italic>\n                      is of global concern due to high levels of multidrug resistance and its propensity to cause infectious outbreaks. Over 90% of isolates are resistant to fluconazole, the most commonly prescribed antifungal worldwide. Fluconazole resistance is multifactorial with many isolates carrying mutations in the gene encoding the transcriptional regulator Tac1B, leading to increased expression of the gene encoding the ATP-binding cassette (ABC) transporter Cdr1. Recently, a study in\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      examining mechanisms of\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      -evolved reduced susceptibility to manogepix, a promising antifungal agent currently in clinical trials, found a\n                      <jats:italic toggle=\"yes\">TAC1B<\/jats:italic>\n                      mutation that confers reduced manogepix and fluconazole susceptibility. We hypothesized that mutations in\n                      <jats:italic toggle=\"yes\">C. auris TAC1B<\/jats:italic>\n                      and similar transcription factors in other\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      species that confer fluconazole resistance might also confer reduced susceptibility to manogepix. We measured manogepix susceptibilities for selected isolates and strains and found that mutations in\n                      <jats:italic toggle=\"yes\">C. auris TAC1B<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">C. parapsilosis TAC1<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">C. glabrata PDR1<\/jats:italic>\n                      confer reduced manogepix susceptibility in a manner dependent on ABC transporters, such as Cdr1. Our findings raise the possibility of fluconazole and manogepix cross-resistance for clinical isolates harboring mutations in these genes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00680-25","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T12:00:50Z","timestamp":1753272050000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in\n                    <i>Candida auris<\/i>\n                    (\n                    <i>Candidozyma auris<\/i>\n                    ),\n                    <i>Candida albicans<\/i>\n                    ,\n                    <i>Candida parapsilosis<\/i>\n                    , and\n                    <i>Candida glabrata<\/i>\n                    (\n                    <i>Nakaseomyces glabratus<\/i>\n                    )"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3824-6829","authenticated-orcid":false,"given":"Katherine S.","family":"Barker","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r3e0967","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacy and Pharmaceutical Sciences, St Jude Children's Research Hospital","place":["Memphis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoja P.","family":"Patterson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology and Laboratory Medicine, Fungus Testing Laboratory, The University of Texas Health Science Center at San Antonio","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-8687","authenticated-orcid":true,"given":"Joachim","family":"Morschh\u00e4user","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Molecular Infection Biology, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Cuomo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05gq02987","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Microbiology and Immunology, Brown University","place":["Providence, USA"]},{"id":[{"id":"https:\/\/ror.org\/05a0ya142","id-type":"ROR","asserted-by":"publisher"}],"name":"Broad Institute","place":["Cambridge, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-5122","authenticated-orcid":true,"given":"Nathan P.","family":"Wiederhold","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology and Laboratory Medicine, Fungus Testing Laboratory, The University of Texas Health Science Center at San Antonio","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4401-0679","authenticated-orcid":true,"given":"P. 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