{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:45:45Z","timestamp":1780623945001,"version":"3.54.1"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["U19 AI089688"],"award-info":[{"award-number":["U19 AI089688"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"HHS | NIH | National Center for Complementary and Integrative Health","award":["R21 AT009174"],"award-info":[{"award-number":["R21 AT009174"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2024,2,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Due to the spread of resistance to front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), a secondary metabolite of a symbiotic bacterium of marine bivalve mollusks, is a promising antimalarial because it inhibits the growth of sexual and asexual blood stages of\n            <jats:italic>Plasmodium falciparum<\/jats:italic>\n            at sub-nanomolar levels. The potency of TrtE warrants further investigation into its mechanism of action, cytotoxicity, and ease with which parasites may evolve resistance to it.\n          <\/jats:p>","DOI":"10.1128\/aac.00684-23","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T14:00:23Z","timestamp":1704808823000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual\n            <i>Plasmodium falciparum<\/i>"],"prefix":"10.1128","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2829-902X","authenticated-orcid":true,"given":"Laura","family":"Chery-Karschney","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapatbhorn","family":"Patrapuvich","sequence":"additional","affiliation":[{"name":"Drug Research Unit for Malaria, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devaraja Gouda","family":"Mudeppa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreekanth","family":"Kokkonda","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0336-7428","authenticated-orcid":true,"given":"Rimi","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Washington, Seattle, Washington, USA"},{"name":"Department of Medicine, Goa Medical College and Hospital, Bambolim, Goa, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patchara","family":"Sriwichai","sequence":"additional","affiliation":[{"name":"Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta M.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradipsinh K.","family":"Rathod","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"White","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"World malaria report","author":"WHO","year":"2022","unstructured":"WHO. 2022. 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