{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:22:57Z","timestamp":1792732977250,"version":"4.5.0"},"reference-count":11,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n The present study demonstrates the efficacy of anidulafungin on mature\n Candida albicans<\/jats:italic>\n biofilms\n in vivo<\/jats:italic>\n . One hundred fifty-seven catheter fragments challenged with\n C. albicans<\/jats:italic>\n were implanted subcutaneously in rats. After formation of biofilms, rats were treated with daily intraperitoneal injections of anidulafungin for 7 days. Catheters retrieved from treated animals showed reduced cell numbers compared to those retrieved from untreated and fluconazole-treated animals. Systemic administration of anidulafungin is promising for the treatment of mature\n C. albicans<\/jats:italic>\n biofilms.\n <\/jats:p>","DOI":"10.1128\/aac.00697-10","type":"journal-article","created":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T00:51:41Z","timestamp":1280191901000},"page":"4474-4475","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":66,"title":["In Vivo<\/i>\n Efficacy of Anidulafungin against Mature\n Candida albicans<\/i>\n Biofilms in a Novel Rat Model of Catheter-Associated Candidiasis"],"prefix":"10.1128","volume":"54","author":[{"given":"Son\u030ca","family":"Kuchari\u0301kova\u0301","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology, VIB, K.U. Leuven, Leuven, Belgium"},{"name":"Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, K.U. Leuven, Leuven, Belgium"},{"name":"Department of Microbiology and Virology, Comenius University, Bratislava, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He\u0301le\u0300ne","family":"Tournu","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, VIB, K.U. Leuven, Leuven, Belgium"},{"name":"Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, K.U. Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Holtappels","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, VIB, K.U. Leuven, Leuven, Belgium"},{"name":"Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, K.U. Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Van Dijck","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, VIB, K.U. Leuven, Leuven, Belgium"},{"name":"Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, K.U. Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Lagrou","sequence":"additional","affiliation":[{"name":"Department of Medical Diagnostic Sciences, K.U. 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