{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:41:23Z","timestamp":1791996083358,"version":"4.4.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Limited data on the clinical outcome of vancomycin treatment compared with that of beta-lactam treatment in patients with methicillin-susceptible\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    bacteremia (MSSA-B) are available. We used different and complementary approaches: (i) a retrospective cohort study using a propensity score to adjust for confounding by treatment assignment and (ii) a matched case-control study. Of all patients with\n                    <jats:italic>S. aureus<\/jats:italic>\n                    bacteremia (SAB) in two university-affiliated hospitals over a 7-year period, 294 patients with MSSA-B were enrolled in the cohort study. The cases for the case-control study were defined as patients who received vancomycin treatment for MSSA-B; the controls, who were patients that received beta-lactam treatment for MSSA-B, were selected at a 1:2 (case:control) ratio according to the objective matching scoring system and the propensity score system. In the cohort study, SAB-related mortality in patients with vancomycin treatment (37%, 10\/27) was significantly higher than that in those with beta-lactam treatment (18%, 47\/267) (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.02). In addition, multivariate analysis revealed that vancomycin treatment was associated with SAB-related mortality when independent predictors for SAB-related mortality and propensity score were considered (adjusted odds ratio of 3.3, 95% confidence interval of 1.2 to 9.5). In the case-control study using the objective matching scoring system and the propensity score system, SAB-related mortality in case patients was 37% (10\/27) and in control patients 11% (6\/54) (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01). Our data suggest that vancomycin is inferior to beta-lactam in the treatment of MSSA-B.\n                  <\/jats:p>","DOI":"10.1128\/aac.00700-07","type":"journal-article","created":{"date-parts":[[2007,11,5]],"date-time":"2007-11-05T20:45:24Z","timestamp":1194295524000},"page":"192-197","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":263,"title":["Outcome of Vancomycin Treatment in Patients with Methicillin-Susceptible\n                    <i>Staphylococcus aureus<\/i>\n                    Bacteremia"],"prefix":"10.1128","volume":"52","author":[{"given":"Sung-Han","family":"Kim","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine"},{"name":"Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kye-Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Bin","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam-Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui-Chong","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, Seoul National University College of Medicine"},{"name":"Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung-don","family":"Oh","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine"},{"name":"Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Won","family":"Choe","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine"},{"name":"Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/1120009X.1991.11739072","volume":"3","year":"1991","unstructured":"Apellaniz, G., M. Valdes, R. Perez, F. Martin, F. Soria, A. Garcia, J. Gomez, and T. Vicente. 1991. Comparison of the effectiveness of various antibiotics in the treatment of methicillin-susceptible Staphylococcus aureus experimental infective endocarditis. J. Chemother.3:91-97.","journal-title":"J. Chemother."},{"key":"e_1_3_1_3_2","first-page":"583","year":"1997","unstructured":"Chambers, H. F. 1997. Parenteral antibiotics for the treatment of bacteremia and other serious staphylococcal infections, p. 583-601. In K. B. Crossley and G. L. Archer (ed.), The staphylococci in human disease. Churchill Livingstone, Inc., New York, NY.","journal-title":"The staphylococci in human disease."},{"key":"e_1_3_1_4_2","first-page":"63","volume":"33","year":"2000","unstructured":"Chang, F. Y. 2000. Staphylococcus aureus bacteremia and endocarditis. J. Microbiol. Immunol. Infect.33:63-68.","journal-title":"J. Microbiol. Immunol. 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Pharmacotherapy17:990-997.","journal-title":"Pharmacotherapy"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/313440"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.2.182"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540500372846"},{"key":"e_1_3_1_12_2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1086\/502157","volume":"24","year":"2003","unstructured":"Kim, S. H., C. I. Kang, H. B. Kim, S. S. Youn, M. D. Oh, E. C. Kim, S. Y. Park, B. K. Kim, and K. W. Choe. 2003. Staphylococcus aureus bacteremia and outcomes of Hickman catheter salvage in febrile neutropenic cancer patients. Infect. Control Hosp. Epidemiol.24:897-904.","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01294.x"},{"key":"e_1_3_1_14_2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jac\/dkh366","volume":"54","year":"2004","unstructured":"Kim, S. H., W. B. Park, K. D. Lee, C. I. Kang, J. W. Bang, H. B. Kim, M. D. Oh, E. C. Kim, and K. W. Choe. 2004. Outcome of inappropriate initial antimicrobial treatment in patients with methicillin-resistant Staphylococcus aureus bacteraemia. J. Antimicrob. Chemother.54:489-497.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_1_15_2","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1086\/377540","volume":"37","year":"2003","unstructured":"Kim, S. H., W. B. Park, K. D. Lee, C. I. Kang, H. B. Kim, M. D. Oh, E. C. Kim, and K. W. Choe. 2003. Outcome of Staphylococcus aureus bacteremia in patients with eradicable foci versus noneradicable foci. Clin. Infect. Dis.37:794-799.","journal-title":"Clin. Infect. 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