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Because biofilm formation is accompanied by high phenotypic resistance of the embedded bacteria, they are almost impossible to eradicate by conventional antibiotics. Therefore, alternative therapeutic strategies are of high interest. We generated nanostructured hybrid nonwovens via the electrospinning of a photoresponsive carbon monoxide (CO)-releasing molecule [CORM-1, Mn\n            <jats:sub>2<\/jats:sub>\n            (CO)\n            <jats:sub>10<\/jats:sub>\n            ] and the polymer polylactide. This nonwoven showed a CO-induced antimicrobial activity that was sufficient to reduce the biofilm-embedded bacteria by 70% after photostimulation at 405 nm. The released CO increased the concentration of reactive oxygen species (ROS) in the biofilms, suggesting that in addition to inhibiting the electron transport chain, ROS might play a role in the antimicrobial activity of CORMs on\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n            . The nonwoven showed increased cytotoxicity on eukaryotic cells after longer exposure, most probably due to the released lactic acid, that might be acceptable for local and short-time treatments. Therefore, CO-releasing nonwovens might be a promising local antimicrobial therapy against biofilm-associated skin wound infections.\n          <\/jats:p>","DOI":"10.1128\/aac.00703-16","type":"journal-article","created":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T04:08:19Z","timestamp":1461643699000},"page":"4037-4046","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Bactericidal Effect of a Photoresponsive Carbon Monoxide-Releasing Nonwoven against Staphylococcus aureus Biofilms"],"prefix":"10.1128","volume":"60","author":[{"given":"Mareike","family":"Klinger-Strobel","sequence":"first","affiliation":[{"name":"Center for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany"},{"name":"Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Gl\u00e4ser","sequence":"additional","affiliation":[{"name":"Friedrich Schiller University Jena, Institute for Inorganic and Analytical Chemistry, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliwia","family":"Makarewicz","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany"},{"name":"Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Wyrwa","sequence":"additional","affiliation":[{"name":"Innovent e.V., Biomaterials Department, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Weisser","sequence":"additional","affiliation":[{"name":"Innovent e.V., Biomaterials Department, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias W.","family":"Pletz","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany"},{"name":"Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Schiller","sequence":"additional","affiliation":[{"name":"Friedrich Schiller University Jena, Institute for Inorganic and Analytical Chemistry, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv179"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00591-15"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00134-14"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12004"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.2.185"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.4.999-1007.2001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.317-323.2003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.7.1818-1824.2000"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-9912-2-30"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-122804"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2013.10.015"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3228"},{"key":"e_1_3_3_14_2","volume-title":"The smallest biomolecules: diatomics and their interactions with heme proteins","author":"Spiro TG","year":"2008","unstructured":"Spiro TG, Ibrahim M, Wasbotten I. 2008. 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