{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:44:38Z","timestamp":1784933078315,"version":"3.55.0"},"reference-count":11,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2024,10,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              <jats:italic>Acinetobacter baumannii<\/jats:italic>\n              is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new\n              <jats:italic>A. baumannii<\/jats:italic>\n              efflux pump SxtP belonging to the MFS superfamily (\n              <jats:underline>m<\/jats:underline>\n              ajor\n              <jats:underline>f<\/jats:underline>\n              acilitator\n              <jats:underline>s<\/jats:underline>\n              uperfamily), along with its associated activator\n              <jats:underline>L<\/jats:underline>\n              ysR\n              <jats:underline>-<\/jats:underline>\n              type\n              <jats:underline>t<\/jats:underline>\n              ranscriptional\n              <jats:underline>r<\/jats:underline>\n              egulator (LTTR) SxtR, demonstrating their roles in sulfamethoxazole\/trimethoprim (also known as co-trimoxazole or SXT) resistance, surface-associated motility and virulence.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.00712-24","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T13:00:38Z","timestamp":1724850038000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole\/trimethoprim (SXT) and the pathogenesis of\n            <i>Acinetobacter baumannii<\/i>"],"prefix":"10.1128","volume":"68","author":[{"given":"Marc","family":"Gaona","sequence":"first","affiliation":[{"name":"Departament de Gen\u00e8tica i de Microbiologia, Facultat de Bioci\u00e8nces, Universitat Aut\u00f2noma de Barcelona (UAB), Cerdanyola del Vall\u00e8s (Barcelona), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2047-6156","authenticated-orcid":true,"given":"Jordi","family":"Corral","sequence":"additional","affiliation":[{"name":"Departament de Gen\u00e8tica i de Microbiologia, Facultat de Bioci\u00e8nces, Universitat Aut\u00f2noma de Barcelona (UAB), Cerdanyola del Vall\u00e8s (Barcelona), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1369-0197","authenticated-orcid":true,"given":"Susana","family":"Campoy","sequence":"additional","affiliation":[{"name":"Departament de Gen\u00e8tica i de Microbiologia, Facultat de Bioci\u00e8nces, Universitat Aut\u00f2noma de Barcelona (UAB), Cerdanyola del Vall\u00e8s (Barcelona), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4408-013X","authenticated-orcid":false,"given":"Jordi","family":"Barb\u00e9","sequence":"additional","affiliation":[{"name":"Departament de Gen\u00e8tica i de Microbiologia, Facultat de Bioci\u00e8nces, Universitat Aut\u00f2noma de Barcelona (UAB), Cerdanyola del Vall\u00e8s (Barcelona), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0990-4041","authenticated-orcid":true,"given":"Mar\u00eda","family":"P\u00e9rez\u2212Varela","sequence":"additional","affiliation":[{"name":"Departament de Gen\u00e8tica i de Microbiologia, Facultat de Bioci\u00e8nces, Universitat Aut\u00f2noma de Barcelona (UAB), Cerdanyola del Vall\u00e8s (Barcelona), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1135-095X","authenticated-orcid":false,"given":"Jes\u00fas","family":"Aranda","sequence":"additional","affiliation":[{"name":"Departament de Gen\u00e8tica i de Microbiologia, Facultat de Bioci\u00e8nces, Universitat Aut\u00f2noma de Barcelona (UAB), Cerdanyola del Vall\u00e8s (Barcelona), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10020127"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00155-10"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky034"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2008\/022772-0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.17.5576-5584.2004"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-279"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00853-13"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01095-19"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-021-02407-x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.001333"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02190-18"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00712-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00712-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T15:46:47Z","timestamp":1728402407000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00712-24"}},"subtitle":[],"editor":[{"given":"Alessandra","family":"Carattoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,10,8]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10,8]]}},"alternative-id":["10.1128\/aac.00712-24"],"URL":"https:\/\/doi.org\/10.1128\/aac.00712-24","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,8]]},"assertion":[{"value":"2024-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00712-24"}}