{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:52:33Z","timestamp":1791381153052,"version":"4.3.3"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Candida auris<\/jats:italic>\n                      frequently demonstrates resistance to multiple antifungal classes and has been classified as a critical priority pathogen by the World Health Organization and the first fungal pathogen designated an urgent threat by the U.S. Centers for Disease Control and Prevention. Patients with skin colonization face a 7%\u201320% risk of invasive infection, with 30-day mortality of 30%\u201372%. While chlorhexidine gluconate (CHG) is widely used for general skin decolonization, it fails to reliably clear\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      from patient skin, and no proven decolonization protocol exists. We evaluated a novel chloramine-based antiseptic polymer, polyvantoin chlorine (AVA-003).\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      CLSI broth microdilution demonstrated activity against isolates from all four major\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      clades (I\u2013IV), with minimum inhibitory concentrations ranging from 250 to 500 \u00b5g\/mL. Two proof-of-concept experiments using a validated murine model assessed\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      efficacy. Female BALB\/c mice were inoculated with clinical isolate\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      MRL-35368 and treated with 1.2% AVA-003, 2% CHG, or vehicle controls across two phases examining formulation and treatment duration. AVA-003 reduced fungal burden at both ear and dorsal sites compared to untreated and CHG-treated controls. Specifically, 1.2% AVA-003 reduced ear burden versus untreated controls by 3.07 log colony-forming units (CFU)\/g (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003, phase I) and versus 2% CHG at 3 days by 1.42 log CFU\/g (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001, phase II); dorsal burden was reduced by 3.58 log CFU\/g versus untreated controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). In phase I, 1.2% AVA-003 achieved undetectable burden (0 CFU\/g) at both sites. In phase II, AVA-003 significantly reduced but did not uniformly eradicate\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      burden. Its advantage over CHG was greater at 3 days than 7 days, likely reflecting progressive dorsal hair regrowth, a recognized limitation of the murine model. These findings support AVA-003 as a promising\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      decolonization candidate warranting further clinical investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00713-26","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:08:42Z","timestamp":1787321322000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["A chloramine-based antiseptic polymer improves\n                    <i>Candida auris<\/i>\n                    skin decolonization compared to chlorhexidine in a murine model"],"prefix":"10.1128","volume":"70","author":[{"given":"Janet","family":"Herrada","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Dermatology, School of Medicine, Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Long","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Dermatology, School of Medicine, Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5998-6423","authenticated-orcid":true,"given":"Erin Marie","family":"San Valentin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Dermatology, School of Medicine, Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0069-2196","authenticated-orcid":false,"given":"Fnu","family":"Samiksha","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Dermatology, School of Medicine, Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Byrnes-Shaver","sequence":"additional","affiliation":[{"name":"iFyber, LLC","place":["Ithaca, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Harding","sequence":"additional","affiliation":[{"name":"iFyber, LLC","place":["Ithaca, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"McCormick","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Dermatology, School of Medicine, Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8833-7323","authenticated-orcid":true,"given":"Mahmoud","family":"Ghannoum","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Dermatology, School of Medicine, Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","unstructured":"Centers for Disease Control and Prevention. 2019. 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