{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:01:21Z","timestamp":1791313281735,"version":"4.3.1"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Urinary catheters are widely used for hospitalized patients and are often associated with high rates of urinary tract infection. We evaluated in vitro the antiadherence activity of a novel antiseptic Gendine-coated urinary catheter against several multidrug-resistant bacteria. Gendine-coated urinary catheters were compared to silver hydrogel-coated Foley catheters and uncoated catheters. Bacterial biofilm formation was assessed by quantitative culture and scanning electron microscopy. These data were further correlated to an in vivo rabbit model. We challenged 31 rabbits daily for 4 days by inoculating the urethral meatus with 1.0 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    CFU streptomycin-resistant\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    per day. In vitro, Gendine-coated urinary catheters reduced the CFU of all organisms tested for biofilm adherence compared with uncoated and silver hydrogel-coated catheters (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.004). Scanning electron microscopy analysis showed that a thick biofilm overlaid the control catheter and the silver hydrogel-coated catheters but not the Gendine-coated urinary catheter. Similar results were found with the rabbit model. Bacteriuria was present in 60% of rabbits with uncoated catheters and 71% of those with silver hydrogel-coated catheters (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01) but not in those with Gendine-coated urinary catheters. No rabbits with Gendine-coated urinary catheters had invasive bladder infections. Histopathologic assessment revealed no differences in toxicity or staining. Gendine-coated urinary catheters were more efficacious in preventing catheter-associated colonization and urinary tract infections than were silver hydrogel-coated Foley catheters and uncoated catheters.\n                  <\/jats:p>","DOI":"10.1128\/aac.00718-09","type":"journal-article","created":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T21:21:07Z","timestamp":1254777667000},"page":"5145-5149","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":77,"title":["Novel Antiseptic Urinary Catheters for Prevention of Urinary Tract Infections: Correlation of In Vivo and In Vitro Test Results"],"prefix":"10.1128","volume":"53","author":[{"given":"Ray","family":"Hachem","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Reitzel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agatha","family":"Borne","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Tinkey","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Uthamanthil","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotsna","family":"Chandra","sequence":"additional","affiliation":[{"name":"University Hospitals and Case Medical Center and Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Ghannoum","sequence":"additional","affiliation":[{"name":"University Hospitals and Case Medical Center and Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issam","family":"Raad","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)56652-5"},{"key":"e_1_3_2_3_2","first-page":"783","volume":"41","year":"1992","unstructured":"Centers for Disease Control. 1992. Public health focus: surveillance, prevention, and control of nosocomial infections. MMWR Morb. Mortal. Wkly. Rep.41:783-787.","journal-title":"MMWR Morb. Mortal. Wkly. 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Academic Press, London, United Kingdom.","journal-title":"Handbook of animal models of infection"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199905000-00020"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80313-1"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1965.tb09575.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.17.2670"},{"key":"e_1_3_2_21_2","first-page":"225","volume":"31","year":"1995","unstructured":"Saji, M., S. Taguchi, K. Uchiyama, E. Osono, N. Hayama, and H. Ohkuni. 1995. Efficacy of gentian violet in the eradication of methicillin-resistant Staphylococcus aureus from skin lesions. J. Hosp. Infect.31:225-228.","journal-title":"J. Hosp. 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