{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:51:36Z","timestamp":1760385096033},"reference-count":19,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n We investigated possible cross talk between endogenous antioxidants glutathione, spermidine, and glutathionylspermidine and drug efflux in\n Escherichia coli<\/jats:italic>\n . We found that cells lacking either spermidine or glutathione are less susceptible than the wild type to novobiocin and certain aminoglycosides. In contrast, exogenous glutathione protects against both bactericidal and bacteriostatic antibiotics. The glutathione protection does not require the AcrAB efflux pump but fails in cells lacking TolC because exogenous glutathione is toxic to these cells.\n <\/jats:p>","DOI":"10.1128\/aac.00719-10","type":"journal-article","created":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T04:44:26Z","timestamp":1285649066000},"page":"5366-5368","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Interplay between Drug Efflux and Antioxidants in\n Escherichia coli<\/i>\n Resistance to Antibiotics"],"prefix":"10.1128","volume":"54","author":[{"given":"Girija","family":"Dhamdhere","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Room 208, Norman, Oklahoma 73019"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganesh","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Room 208, Norman, Oklahoma 73019"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen I.","family":"Zgurskaya","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Room 208, Norman, Oklahoma 73019"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00229-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.23.14031"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2627990100"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120163297"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07245.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100135"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812596106"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1981.tb06330.x"},{"key":"e_1_3_2_10_2","first-page":"360","volume":"59","year":"1981","unstructured":"Goldemberg, S. 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