{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:34:40Z","timestamp":1790987680742,"version":"4.1.0"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82173429"],"award-info":[{"award-number":["No. 82173429"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82102418"],"award-info":[{"award-number":["No. 82102418"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Health and Family Planning Commission","doi-asserted-by":"publisher","award":["No. 201940476"],"award-info":[{"award-number":["No. 201940476"]}],"id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["No. 21Y11904900"],"award-info":[{"award-number":["No. 21Y11904900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,11,15]]},"abstract":"<jats:p>\n            The opportunistic fungal infections are an increasing threat to humans due to the increasing number of patients with immunodeficiency, in which the most popular fungal pathogen is\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            . Fluconazole (FLC) is the common drug for treating\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            infections, but increasing drug resistance has limited its clinical use.\n          <\/jats:p>","DOI":"10.1128\/aac.00725-22","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T13:03:33Z","timestamp":1666789413000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Synergistic Effect of the Combination of Deferoxamine and Fluconazole\n            <i>In Vitro<\/i>\n            and\n            <i>In Vivo<\/i>\n            against Fluconazole-Resistant\n            <i>Candida<\/i>\n            Spp."],"prefix":"10.1128","volume":"66","author":[{"given":"Lulu","family":"An","sequence":"first","affiliation":[{"name":"Department of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyong","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Engineering &amp; Nano Science, Tongji University School of Medicine, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7890-6553","authenticated-orcid":true,"given":"Lianjuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.01.055"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-2021-26"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1476490"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02542-17"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199652020-00005"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161001-00001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.10.025"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/foy025"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0322-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.03.028"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/c7mt00116a"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04214.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.04.010"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00653-06"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02576-17"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2010.01956.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0272-6386(12)80606-8"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3283165fd1"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-016-5628-4"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00286"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2636"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.1.209"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8010048"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.6.2713-2721.1998"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.5.2.347-358.2006"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12659"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.02.008"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2019.04.001"},{"key":"e_1_3_3_30_2","unstructured":"Clinical and Laboratory Standards Institute. 2012. Reference method for broth dilution antifungal susceptibility testing of yeasts; fourth informational supplement. CLSI document M27-S4. CLSI Wayne PA."},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-009-9251-3"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1906s105"},{"key":"e_1_3_3_33_2","first-page":"4109","article-title":"Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice","volume":"46","author":"Naito S","year":"1986","unstructured":"Naito S, von Eschenbach AC, Giavazzi R, Fidler IJ. 1986. Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice. Cancer Res 46:4109\u20134115.","journal-title":"Cancer Res"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00725-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00725-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T13:02:43Z","timestamp":1668517363000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00725-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,15]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11,15]]}},"alternative-id":["10.1128\/aac.00725-22"],"URL":"https:\/\/doi.org\/10.1128\/aac.00725-22","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,15]]},"assertion":[{"value":"2022-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00725-22"}}