{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:01:16Z","timestamp":1773723676761,"version":"3.50.1"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Multidrug resistance (MDR) is a major problem in the treatment of infectious diseases and cancer. Accumulating evidence suggests that the cyclooxygenase-2 (COX-2)-specific inhibitor celecoxib would not only inhibit COX-2 but also help in the reversal of drug resistance in cancers by inhibiting the MDR1 efflux pump. Here, we demonstrate that celecoxib increases the sensitivity of bacteria to the antibiotics ampicillin, kanamycin, chloramphenicol, and ciprofloxacin by accumulating the drugs inside the cell, thus reversing MDR in bacteria.<\/jats:p>","DOI":"10.1128\/aac.00735-10","type":"journal-article","created":{"date-parts":[[2010,10,12]],"date-time":"2010-10-12T05:11:51Z","timestamp":1286860311000},"page":"439-442","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":76,"title":["Inhibition of Bacterial Multidrug Resistance by Celecoxib, a Cyclooxygenase-2 Inhibitor"],"prefix":"10.1128","volume":"55","author":[{"given":"Arunasree M.","family":"Kalle","sequence":"first","affiliation":[{"name":"Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arshad","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Hyderabad, Hyderabad 500046, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.11.007"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00298-08"},{"key":"e_1_3_2_4_2","first-page":"246","volume":"38","year":"2006","unstructured":"Gupta, A. 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