{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:09:00Z","timestamp":1793758140420,"version":"4.6.1"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Spero Therapeutics"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,9,17]]},"abstract":"<jats:p>\n                    Carbapenem-resistant\n                    <jats:named-content content-type=\"genus-species\">Acinetobacter baumannii<\/jats:named-content>\n                    and\n                    <jats:italic>Enterobacterales<\/jats:italic>\n                    are identified as urgent threats, and multidrug-resistant (MDR)\n                    <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n                    and extended-spectrum beta-lactamase (ESBL)-producing pathogens are identified as serious threats by the Centers for Disease Control and Prevention (CDC). SPR206 is a novel polymyxin derivative with potent\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    activity against\n                    <jats:named-content content-type=\"genus-species\">A. baumannii<\/jats:named-content>\n                    ,\n                    <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n                    , and multiple clinically important species of\n                    <jats:italic>Enterobacterales<\/jats:italic>\n                    , including multidrug- and extensively drug-resistant strains.\n                  <\/jats:p>","DOI":"10.1128\/aac.00739-21","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T16:34:55Z","timestamp":1627922095000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Single- and Multiple-Ascending-Dose Study of the Safety, Tolerability, and Pharmacokinetics of the Polymyxin Derivative SPR206"],"prefix":"10.1128","volume":"65","author":[{"given":"Jon","family":"Bruss","sequence":"first","affiliation":[{"name":"Spero Therapeutics Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy","family":"Lister","sequence":"additional","affiliation":[{"name":"Spero Therapeutics Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8093-5126","authenticated-orcid":true,"given":"Vipul K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Spero Therapeutics Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Stone","sequence":"additional","affiliation":[{"name":"Spero Therapeutics Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Morelli","sequence":"additional","affiliation":[{"name":"Spero Therapeutics Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lei","sequence":"additional","affiliation":[{"name":"Spero Therapeutics Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4687-6361","authenticated-orcid":true,"given":"David","family":"Melnick","sequence":"additional","affiliation":[{"name":"Spero Therapeutics Inc., Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization. 2017. Global priority list of antibiotic-resistant bacteria to guide research discovery and development of new antibiotics. World Health Organization Geneva Switzerland. https:\/\/www.who.int\/medicines\/publications\/WHO-PPL-Short_Summary_25Feb-ET_NM_WHO.pdf?ua=1."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.15620\/cdc:82532"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx176"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/668770"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-019-0319-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2404.171461"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy293"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1599225"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000933"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000337"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12363"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001029"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-16"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.2477"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1392-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2507.181200"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02671-16"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2016.22"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000649"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.03.014"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00080"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa439.1478"},{"key":"e_1_3_2_24_2","unstructured":"Arends SJR Rhomberg PR Lister T Cotroneo N Rubio A Flamm RK Mendes RE. 2018. Activity of an investigational polymyxin-b-like compound (SPR206) against a set of Enterobacteriaceae organisms responsible for human infections poster 81. Abstr ESCMID-ASM."},{"key":"e_1_3_2_25_2","unstructured":"Arends SJR Rhomberg PR Lister T Cotroneo N Rubio A Flamm RK Mendes RE. 2019. Activity of an investigational polymyxin-b-like compound (SPR206) against a set of gram-negative bacilli responsible for human infections poster AAR-796. Abstr ASM Microbe."},{"key":"e_1_3_2_26_2","unstructured":"Arends SJR Rhomberg PR Lister T Cotroneo N Rubio A Flamm RK Mendes RE. 2018. In vitro activity evaluation of a next-generation polymyxin SPR206 against non-fermentative gram-negative bacilli responsible for human infections poster 80. Abstr ESCMID-ASM."},{"key":"e_1_3_2_27_2","unstructured":"Cotroneo N Tomich A Zou Y Lister T Brown P Dawson M. 2019. In vitro bactericidal activity of next-generation polymyxin SPR206 against susceptible and multidrug-resistant (MDR) Acinetobacter baumannii Pseudomonas aeruginosa Escherichia coli and Klebsiella pneumoniae as compared to levofloxacin and meropenem poster AAR-797. Abstr ASM Microbe."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa217"},{"key":"e_1_3_2_29_2","unstructured":"Grosser L Heang K Teague J Warn P Corbett D Dawson MJ Rubio A. 2018. In vivo efficacy of SPR206 in murine lung and thigh infection models caused by multidrug resistant pathogens Pseudomonas aeruginosa and Acinetobacter baumannii poster 139. Abstr ESCMID-ASM."},{"key":"e_1_3_2_30_2","unstructured":"Grosser L Lister T Heang K Brown P Dawson M Rubio A. 2019. In vivo efficacy of next-generation polymyxin SPR206 in an immunocompetent murine ascending UTI infection model caused by Escherichia coli poster AAR-798. Abstr ASM Microbe."},{"key":"e_1_3_2_31_2","unstructured":"Grosser L Lister T Heang K Warn P Corbett D Dawson MJ Rubio A. 2019. In vivo efficacy of SPR206 in murine lung and thigh infection models caused by multidrug resistant pathogens Pseudomonas aeruginosa and Acinetobacter baumannii poster AAR-799. Abstr ASM Microbe."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00217"},{"key":"e_1_3_2_33_2","unstructured":"Brown P Boakes S Duperchy E Rivers D Singh J Dawson MJ. 2018. Understanding the SAR interplay for kidney exposure and cytotoxicity facilitates the design of improved polymyxin derivatives\u2014identification of SPR206 as a development candidate poster 145. Abstr ESCMID-ASM."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3995"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200900779"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics8010024"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02319-16"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw250"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2209"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00739-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00739-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T18:30:16Z","timestamp":1645468216000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00739-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,17]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,9,17]]}},"alternative-id":["10.1128\/AAC.00739-21"],"URL":"https:\/\/doi.org\/10.1128\/aac.00739-21","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,17]]},"assertion":[{"value":"2021-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00739-21"}}