{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:27:24Z","timestamp":1787016444102,"version":"build-2736575974"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We investigated the \u03b2-lactam resistance mechanism(s) of an in vitro-selected amoxicillin-resistant\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    strain (AmoxR). Our results demonstrated that resistance is due to a combination of amino acid substitutions in penicillin binding protein 1 (PBP1), HopB, and HopC identified in AmoxR, resulting in decreased affinity of PBP1 for amoxicillin and decreased accumulation of penicillin.\n                  <\/jats:p>","DOI":"10.1128\/aac.00759-06","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T14:39:16Z","timestamp":1164206356000},"page":"4174-4176","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Resistance Mechanisms in an In Vitro-Selected Amoxicillin-Resistant Strain of\n                    <i>Helicobacter pylori<\/i>"],"prefix":"10.1128","volume":"50","author":[{"given":"Edgie-Mark A.","family":"Co","sequence":"first","affiliation":[{"name":"Biomedical Sciences Division, University of California, Riverside, Riverside, California 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal L.","family":"Schiller","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Division, University of California, Riverside, Riverside, California 92521"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3368-3373.2000"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.19.5447-5452.1995"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1006.030744"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.4.720"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.4.1567-1572.1995"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.7.2229-2233.2002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.5.591"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"134s","DOI":"10.1046\/j.1365-2672.2001.01362.x","volume":"90","year":"2001","unstructured":"Kursters, J. G., and E. J. Kuipers. 2001. Antibiotic resistance of Helicobacter pylori. J. Appl. Microbiol.90:134s-144s.","journal-title":"J. Appl. 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