{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T05:33:39Z","timestamp":1769751219152,"version":"3.49.0"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["RalFE 160"],"award-info":[{"award-number":["RalFE 160"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,9,21]]},"abstract":"<jats:p>A population pharmacokinetic model was developed to explore the pharmacokinetics modification of unbound raltegravir during pregnancy. The RalFe ANRS160 study was a nonrandomized, open-label, multicenter trial enrolling HIV-infected pregnant women receiving a combined antiretroviral regimen containing 400\u2009mg raltegravir twice daily. Biological samples were collected during the third trimester of pregnancy (between 30 and 37\u2009weeks of gestational age) and at postpartum (4 to 6\u2009weeks after delivery).<\/jats:p>","DOI":"10.1128\/aac.00759-20","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T14:13:56Z","timestamp":1594736036000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Pregnancy on Unbound Raltegravir Concentrations in the ANRS 160 RalFe Trial"],"prefix":"10.1128","volume":"64","author":[{"given":"Yi","family":"Zheng","sequence":"first","affiliation":[{"name":"Service de Pharmacologie Clinique, AP-HP, H\u00f4pital Cochin, Paris, France"},{"name":"EA7323, Universit\u00e9 de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9898-2609","authenticated-orcid":false,"given":"D\u00e9borah","family":"Hirt","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique, AP-HP, H\u00f4pital Cochin, Paris, France"},{"name":"EA7323, Universit\u00e9 de Paris, Paris, France"},{"name":"Inserm 1018 CESP, H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Delmas","sequence":"additional","affiliation":[{"name":"Service d\u2019Epid\u00e9miologie et Sant\u00e9 Publique, AP-HP, H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle","family":"Lui","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique, AP-HP, H\u00f4pital Cochin, Paris, France"},{"name":"EA7323, Universit\u00e9 de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihem","family":"Benaboud","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique, AP-HP, H\u00f4pital Cochin, Paris, France"},{"name":"EA7323, Universit\u00e9 de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Lechedanec","sequence":"additional","affiliation":[{"name":"Service d\u2019Epid\u00e9miologie et Sant\u00e9 Publique, AP-HP, H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Tr\u00e9luyer","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique, AP-HP, H\u00f4pital Cochin, Paris, France"},{"name":"EA7323, Universit\u00e9 de Paris, Paris, France"},{"name":"Unit\u00e9 de Recherche Clinique Paris Descartes Necker Cochin, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Chenevier-Gobeaux","sequence":"additional","affiliation":[{"name":"Service de Diagnostic Biologique Automatis\u00e9, AP-HP, H\u00f4pital Cochin, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Arezes","sequence":"additional","affiliation":[{"name":"Service d\u2019Epid\u00e9miologie et Sant\u00e9 Publique, AP-HP, H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambre","family":"Gelley","sequence":"additional","affiliation":[{"name":"ANRS, France Recherche Nord&amp;Sud Sida-hiv H\u00e9patites, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imane","family":"Amri","sequence":"additional","affiliation":[{"name":"ANRS, France Recherche Nord&amp;Sud Sida-hiv H\u00e9patites, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa\u00efk","family":"Urien","sequence":"additional","affiliation":[{"name":"EA7323, Universit\u00e9 de Paris, Paris, France"},{"name":"Unit\u00e9 de Recherche Clinique Paris Descartes Necker Cochin, AP-HP, Paris, France"},{"name":"CIC-1419 Inserm, Cochin-Necker, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na\u00efm","family":"Bouazza","sequence":"additional","affiliation":[{"name":"EA7323, Universit\u00e9 de Paris, Paris, France"},{"name":"Unit\u00e9 de Recherche Clinique Paris Descartes Necker Cochin, AP-HP, Paris, France"},{"name":"CIC-1419 Inserm, Cochin-Necker, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frantz","family":"Foissac","sequence":"additional","affiliation":[{"name":"EA7323, Universit\u00e9 de Paris, Paris, France"},{"name":"Unit\u00e9 de Recherche Clinique Paris Descartes Necker Cochin, AP-HP, Paris, France"},{"name":"CIC-1419 Inserm, Cochin-Necker, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josiane","family":"Warszawski","sequence":"additional","affiliation":[{"name":"Inserm 1018 CESP, H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"},{"name":"Service d\u2019Epid\u00e9miologie et Sant\u00e9 Publique, AP-HP, H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jade","family":"Ghosn","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, AP-HP, H\u00f4pitaux Universitaires Paris Nord Val de Seine, site Bichat-Claude Bernard, Paris, France"},{"name":"INSERM UMR 1137 IAME, Universit\u00e9 Paris Diderot, Facult\u00e9 de M\u00e9decine site Bichat, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Global guidance on criteria and processes for validation: elimination of Mother-to-Child Transmission of HIV and Syphilis","author":"WHO","year":"2020","unstructured":"WHO. 2020. Global guidance on criteria and processes for validation: elimination of Mother-to-Child Transmission of HIV and Syphilis. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200204150-00009"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f9b67a"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511691"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)11046-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f3d63c"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002375"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3397-x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411033311801"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31802b4956"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60597-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318157131c"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(18)30059-6"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-018-2352-2"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1626"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ366"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000318"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25803-z"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.050585397"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04594-14"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw215"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100281"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw388"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03220.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx176"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.2165\/11597440-000000000-00000"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx275"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.08.054"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-018-0684-z"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1053\/beog.2001.0231"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.016196"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/00498250701744633"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-005-1750-9"},{"key":"e_1_3_2_35_2","volume-title":"Isentress: summary of product characteristics","author":"European Medicines Agency","year":"2007","unstructured":"European Medicines Agency. 2007. Isentress: summary of product characteristics. European Medicines Agency, Amsterdam, the Netherlands."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2020.113119"},{"key":"e_1_3_2_37_2","volume-title":"Bioanalytical method validation guidance for industry","author":"FDA","year":"2019","unstructured":"FDA. 2019. Bioanalytical method validation guidance for industry. US Food Drug Administration, Washington, DC."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00863-15"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00166-11"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.8170"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06417-11"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00625-13"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00759-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00759-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:33:21Z","timestamp":1645486401000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00759-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,9,21]]}},"alternative-id":["10.1128\/AAC.00759-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.00759-20","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,21]]},"assertion":[{"value":"2020-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00759-20"}}