{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:18:29Z","timestamp":1791494309464,"version":"4.3.4"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>We describe a case of apparent mineralocorticoid excess (AME) secondary to posaconazole therapy and suggest the biochemical mechanism. Clinical and laboratory investigation confirmed 11\u03b2-hydroxysteroid dehydrogenase inhibition and withholding therapy led to a resolution of all clinical and laboratory abnormalities. Posaconazole was later restarted at a lower dose and prevented recurrence of this syndrome. Additional studies are necessary to determine the frequency of posaconazole-induced AME and whether other azole antifungals can be associated with this phenomenon.<\/jats:p>","DOI":"10.1128\/aac.00760-17","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:31:13Z","timestamp":1495499473000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["<i>In Vivo<\/i>\n            11\u03b2-Hydroxysteroid Dehydrogenase Inhibition in Posaconazole-Induced Hypertension and Hypokalemia"],"prefix":"10.1128","volume":"61","author":[{"suffix":"III","given":"George R.","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of California\u2013Davis, Davis, California, USA"},{"name":"Department of Internal Medicine, Division of Infectious Diseases, University of California Davis Medical Center, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of California Davis Medical Center, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca R.","family":"Wittenberg","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of California Davis Medical Center, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"McHardy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of California\u2013Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Semrad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, University of California Davis Medical Center, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04035-14"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12452"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/508774"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.01.010"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1212128"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(01)00117-9"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.18.1.0288"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1340267"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.132.6.8504732"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2012"},{"key":"e_1_3_2_13_2","volume-title":"Posaconazole package insert","author":"Merck & Co., Inc","year":"2014","unstructured":"Merck & Co., Inc. 2014. 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Merck & Co., Inc.,Whitehouse Station, NJ."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00019-17"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25568"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110243251706"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(96)90025-9"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00760-17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00760-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:05:36Z","timestamp":1645477536000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00760-17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1128\/AAC.00760-17"],"URL":"https:\/\/doi.org\/10.1128\/aac.00760-17","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"2017-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00760-17"}}