{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:02:04Z","timestamp":1791414124249,"version":"4.3.3"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            DA-7867 and DA-7157 are oxazolidinones active against pathogenic aerobic actinomycetes including\n            <jats:italic>Nocardia<\/jats:italic>\n            spp. and\n            <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n            . However, the activity of these drugs against nontuberculous mycobacterium (NTM) species is not known. In this work, we compared the susceptibilities of 122 clinical isolates and 29 reference species of both rapidly growing and slowly growing mycobacteria to linezolid, DA-7867, and DA-7157 by the broth microdilution method. The MICs for 50 and 90% of the strains tested (MIC\n            <jats:sub>50<\/jats:sub>\n            s and MIC\n            <jats:sub>90<\/jats:sub>\n            s, respectively) of DA-7867 and DA-7157 were lower than those of linezolid. In all of the cases, a MIC\n            <jats:sub>90<\/jats:sub>\n            of &lt;8 \u03bcg\/ml was observed for all of the species tested in both groups of NTM. For\n            <jats:italic>M. kansasii<\/jats:italic>\n            and\n            <jats:italic>M. marinum<\/jats:italic>\n            isolates, the MIC\n            <jats:sub>90<\/jats:sub>\n            s of both DA-7867 and DA-7157 were less than 0.5 \u03bcg\/ml. These results demonstrate the potential of these compounds to treat NTM infections.\n          <\/jats:p>","DOI":"10.1128\/aac.00763-06","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T19:39:16Z","timestamp":1164224356000},"page":"4027-4029","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["In Vitro Activities of the Novel Oxazolidinones DA-7867 and DA-7157 against Rapidly and Slowly Growing Mycobacteria"],"prefix":"10.1128","volume":"50","author":[{"given":"Lucio","family":"Vera-Cabrera","sequence":"first","affiliation":[{"name":"Servicio de Dermatologi\u0301a, Hospital Universitario Jose\u0301 E. Gonza\u0301lez, Monterrey, N.L., Me\u0301xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Brown-Elliott","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Texas Health Center, Tyler, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Richard J.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Texas Health Center, Tyler, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Ocampo-Candiani","sequence":"additional","affiliation":[{"name":"Servicio de Dermatologi\u0301a, Hospital Universitario Jose\u0301 E. Gonza\u0301lez, Monterrey, N.L., Me\u0301xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliverio","family":"Welsh","sequence":"additional","affiliation":[{"name":"Servicio de Dermatologi\u0301a, Hospital Universitario Jose\u0301 E. Gonza\u0301lez, Monterrey, N.L., Me\u0301xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hak","family":"Choi","sequence":"additional","affiliation":[{"name":"Research Laboratory, Dong-A Pharmaceutical Co., Ltd., Yongin, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen A.","family":"Molina-Torres","sequence":"additional","affiliation":[{"name":"Servicio de Dermatologi\u0301a, Hospital Universitario Jose\u0301 E. Gonza\u0301lez, Monterrey, N.L., Me\u0301xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106753"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/322523"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.5.1736-1738.2003"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/504381"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.2.566"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki148"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/345907"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2002.0970"},{"key":"e_1_3_1_10_2","unstructured":"National Committee for Clinical Laboratory Standards. 2003. Susceptibility testing of mycobacteria nocardiae and other aerobic actinomycetes; approved standard. NCCLS document M24-A. National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki319"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.8.8.1195"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.31.2.175-178.1993"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.2.319-354.2003"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.3.1037-1039.2004"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00571-06"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.2.602-604.2004"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.764-767.2001"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.6.1958-1962.2003"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00763-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00763-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T18:58:31Z","timestamp":1645469911000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00763-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1128\/AAC.00763-06"],"URL":"https:\/\/doi.org\/10.1128\/aac.00763-06","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]},"assertion":[{"value":"2006-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}