{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:13:45Z","timestamp":1792116825145,"version":"4.4.0"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Acinetobacter baumannii<\/jats:italic>\n            isolate AP was recovered from a bronchial lavage of a patient hospitalized in Paris, France.\n            <jats:italic>A. baumannii<\/jats:italic>\n            AP was resistant to all \u03b2-lactams, including carbapenems, and produced the extended-spectrum \u03b2-lactamase (ESBL) GES-14, which differs from GES-1 by two substitutions, Gly170Ser and Gly243Ala. Cloning of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>GES-14<\/jats:sub>\n            gene followed by its expression in\n            <jats:italic>Escherichia coli<\/jats:italic>\n            showed that GES-14 compromised significantly the efficacy of all \u03b2-lactams, including cephalosporins, aztreonam, and carbapenems. The carbapenemase activity of purified GES-14 was confirmed by kinetic studies. The\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>GES-14<\/jats:sub>\n            gene was located into a class 1 integron structure and located onto a ca. 95-kb self-transferable plasmid. This study identified a very broad-spectrum \u03b2-lactamase in\n            <jats:italic>A. baumannii<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.00773-10","type":"journal-article","created":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T03:54:41Z","timestamp":1287460481000},"page":"349-354","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":109,"title":["Carbapenem-Hydrolyzing GES-Type Extended-Spectrum \u03b2-Lactamase in\n            <i>Acinetobacter baumannii<\/i>"],"prefix":"10.1128","volume":"55","author":[{"given":"Re\u0301my A.","family":"Bonnin","sequence":"first","affiliation":[{"name":"Service de Bacte\u0301riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, Ho\u0302pital de Bice\u0302tre, Assistance Publique\/Ho\u0302pitaux de Paris, Faculte\u0301 de Me\u0301decine et Universite\u0301 Paris-Sud, Le 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herve\u0301","family":"Lecuyer","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie Hygie\u0300ne Hospitalie\u0300re, Ho\u0302pital Necker-Enfants Malades Assistance Publique-Ho\u0302pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Ralph","family":"Zahar","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie Hygie\u0300ne Hospitalie\u0300re, Ho\u0302pital Necker-Enfants Malades Assistance Publique-Ho\u0302pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Poirel","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, Ho\u0302pital de Bice\u0302tre, Assistance Publique\/Ho\u0302pitaux de Paris, Faculte\u0301 de Me\u0301decine et Universite\u0301 Paris-Sud, Le 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