{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:54:07Z","timestamp":1760648047634,"version":"3.41.2"},"reference-count":7,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"AFHSD-GEIS","award":["P0005_19_AF"],"award-info":[{"award-number":["P0005_19_AF"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2024,9,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Despite the overall decline in malaria cases in Thailand, continuous surveillance in endemic areas remains crucial. This retrospective analysis examined\n              <jats:italic>Plasmodium falciparum<\/jats:italic>\n              samples from Tak province, Thailand, collected in 1998, 1999, and 2001, to investigate the prevalence and evolution of antimalarial genotypic drug resistance. The study revealed a high prevalence of drug-resistant\n              <jats:italic>P. falciparum<\/jats:italic>\n              , particularly to mefloquine and sulfadoxine\/pyrimethamine, with significant mutations in genes associated with resistance. Notably, mutations indicative of artemisinin resistance, such as those in the kelch13 gene, were detected at low frequencies, suggesting an evolving resistance pattern. The underlying cause of these resistance mutations appears to be the historical and widespread use of these antimalarial drugs, which exerted selective pressure on the parasite population. These findings underscore the necessity of ongoing surveillance and adaptive control strategies to manage drug resistance, guide treatment policies, and prevent potential outbreaks, even as malaria cases decrease. Continuous monitoring and research are imperative to sustain malaria elimination efforts and address the dynamic challenges posed by evolving drug-resistant strains.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.00779-24","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T13:02:24Z","timestamp":1723554144000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence and dynamics of antimalarial drug resistance mutations among the\n            <i>Plasmodium falciparum<\/i>\n            isolates in TAK Province, Thailand, during the period of 1998\u20132001"],"prefix":"10.1128","volume":"68","author":[{"given":"Sasikanya","family":"Thaloengsok","sequence":"first","affiliation":[{"name":"Walter Reed Army Institute of Medical Science-Armed Forces Research Institute of Medical Sciences (WRAIR-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaiyaporn","family":"Chaisatit","sequence":"additional","affiliation":[{"name":"Walter Reed Army Institute of Medical Science-Armed Forces Research Institute of Medical Sciences (WRAIR-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyaporn","family":"Saingam","sequence":"additional","affiliation":[{"name":"Walter Reed Army Institute of Medical Science-Armed Forces Research Institute of Medical Sciences (WRAIR-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2993-9794","authenticated-orcid":false,"given":"Paphavee","family":"Lertsethtakarn","sequence":"additional","affiliation":[{"name":"Walter Reed Army Institute of Medical Science-Armed Forces Research Institute of Medical Sciences (WRAIR-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2921-9677","authenticated-orcid":true,"given":"Michele","family":"Spring","sequence":"additional","affiliation":[{"name":"Walter Reed Army Institute of Medical Science-Armed Forces Research Institute of Medical Sciences (WRAIR-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabaithip","family":"Sriwichai","sequence":"additional","affiliation":[{"name":"Walter Reed Army Institute of Medical Science-Armed Forces Research Institute of Medical Sciences (WRAIR-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suporn","family":"Pholwat","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6301-4563","authenticated-orcid":true,"given":"Jennifer L.","family":"Guler","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA"},{"name":"Department of Biology, University of Virginia, Charlottesville, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric R.","family":"Houpt","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5708-5782","authenticated-orcid":true,"given":"Brian A.","family":"Vesely","sequence":"additional","affiliation":[{"name":"Walter Reed Army Institute of Medical Science-Armed Forces Research Institute of Medical Sciences (WRAIR-AFRIMS), Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.18-0897"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314981"},{"key":"e_1_3_3_4_2","unstructured":"World Health Organization. 2022. Artemisinin resistance and artemisinin-based combination therapy efficacy. World Health Organization. Available from: https:\/\/www.who.int\/news-room\/feature-stories\/detail\/artemisinin-resistance-and-artemisinin-based-combination-therapy-efficacy"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513137"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00110-17"},{"key":"e_1_3_3_7_2","article-title":"Prevalence of drug-resistant malaria in asymptomatic populations in Myanmar: a nationwide study","author":"Zaw MT","year":"2020","unstructured":"Zaw MT, Hlaing TA, Kyaw AMT, Myint CWW, Yonemori J, Tyner SD, Maung NS, Nagao K. 2020. Prevalence of drug-resistant malaria in asymptomatic populations in Myanmar: a nationwide study. J Infect Dis DOI: 10.1093\/infdis\/jiz607","journal-title":"J Infect Dis DOI: 10.1093\/infdis\/jiz607"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.4.971"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00779-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00779-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T15:07:30Z","timestamp":1726672050000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00779-24"}},"subtitle":[],"editor":[{"given":"Audrey","family":"Odom John","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":7,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9,4]]}},"alternative-id":["10.1128\/aac.00779-24"],"URL":"https:\/\/doi.org\/10.1128\/aac.00779-24","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"type":"print","value":"0066-4804"},{"type":"electronic","value":"1098-6596"}],"subject":[],"published":{"date-parts":[[2024,9,4]]},"assertion":[{"value":"2024-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00779-24"}}