{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:03:46Z","timestamp":1787508226379,"version":"build-2736575974"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19jm0110015"],"award-info":[{"award-number":["JP19jm0110015"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19fk0108094"],"award-info":[{"award-number":["JP19fk0108094"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,8,20]]},"abstract":"<jats:p>\n                    Infections caused by\n                    <jats:named-content content-type=\"genus-species\">Candida glabrata<\/jats:named-content>\n                    have caused worldwide concern, especially when they are associated with increasing echinocandin and azole resistance. In this study, we analyzed the molecular mechanisms of azole and echinocandin resistance in\n                    <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n                    isolates obtained from hospitalized patients in Japan from 1997 to 2019. All isolates were checked phenotypically for resistance and genotypically for mutations in\n                    <jats:italic>PDR1<\/jats:italic>\n                    ,\n                    <jats:italic>ERG11<\/jats:italic>\n                    , hot spot 1 (HS1), HS2, and HS3 of\n                    <jats:italic>FKS1<\/jats:italic>\n                    , and HS1 and HS2 of\n                    <jats:italic>FKS2<\/jats:italic>\n                    , and all isolates were genotyped by multilocus sequence typing (MLST).\n                  <\/jats:p>","DOI":"10.1128\/aac.00783-20","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T10:06:05Z","timestamp":1592820365000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["Genetic Basis of Azole and Echinocandin Resistance in Clinical Candida glabrata in 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