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Antibiotic resistance is a major concern, as this organism has a wide variety of resistance mechanisms, including chromosomal class C (\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>PDC<\/jats:sub>\n                      ) and D (\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>OXA-50<\/jats:sub>\n                      family) \u03b2-lactamases, efflux pumps, porin channels, and the ability to readily acquire additional \u03b2-lactamases. Surveillance studies can reveal the diversity and distribution of \u03b2-lactamase alleles but are difficult and expensive to conduct. Herein, we apply a novel approach, using publicly available data derived from whole genome sequences, to explore the diversity and distribution of \u03b2-lactamase alleles across 30,452\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>aeruginosa<\/jats:italic>\n                      isolates. The most common alleles were\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>PDC-3<\/jats:sub>\n                      ,\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>PDC-5<\/jats:sub>\n                      ,\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>PDC-8<\/jats:sub>\n                      ,\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>OXA-488<\/jats:sub>\n                      ,\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>OXA-50<\/jats:sub>\n                      , and\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>OXA-486<\/jats:sub>\n                      . Interestingly, only 43.6% of assigned\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>PDC<\/jats:sub>\n                      alleles were encountered, and the 10 most common\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>PDC<\/jats:sub>\n                      and intrinsic\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>OXA<\/jats:sub>\n                      alleles represent approximately 75% of their respective total alleles, while many other assigned alleles were extremely uncommon. As anticipated, differences were observed over time and geography. Surprisingly, more distinct unassigned alleles were encountered than distinct assigned alleles. Understanding the diversity and distribution of \u03b2-lactamase alleles helps to prioritize variants for further research, select targets for drug development, and may aid in selecting therapies for a given infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00785-24","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T09:01:20Z","timestamp":1739178080000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["\u03b2-Lactamase diversity in\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-7996","authenticated-orcid":true,"given":"Andrew R.","family":"Mack","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine","place":["Cleveland, USA"]},{"name":"Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Hujer","sequence":"additional","affiliation":[{"name":"Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center","place":["Cleveland, USA"]},{"name":"Department of Medicine, Case Western Reserve University School of Medicine","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-9824","authenticated-orcid":true,"given":"Maria F.","family":"Mojica","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine","place":["Cleveland, USA"]},{"name":"Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center","place":["Cleveland, USA"]},{"name":"CWRU-Cleveland VAMC 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