{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:42:25Z","timestamp":1761237745550},"reference-count":23,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We have determined the\n            <jats:italic>in vitro<\/jats:italic>\n            activities of amphotericin B (AMB), voriconazole, posaconazole (PSC), itraconazole (ITC), ravuconazole, terbinafine, and caspofungin against five strains of\n            <jats:italic>Cunninghamella bertholletiae<\/jats:italic>\n            and four of\n            <jats:italic>Cunninghamella echinulata<\/jats:italic>\n            . The best activity was shown by terbinafine against both species (MIC range = 0.3 to 0.6 \u03bcg\/ml) and PSC against\n            <jats:italic>Cunninghamella bertholletiae<\/jats:italic>\n            (MIC = 0.5 \u03bcg\/ml). We have also evaluated the efficacies of PSC, ITC, and AMB in neutropenic and diabetic murine models of disseminated infection by\n            <jats:italic>Cunninghamella bertholletiae<\/jats:italic>\n            . PSC at 40, 60, or 80 mg\/kg of body weight\/day was as effective as AMB at 0.8 mg\/kg\/day in prolonging survival and reducing the fungal tissue burden in neutropenic mice. PSC at 80 mg\/kg\/day was more effective than AMB at 0.8 mg\/kg\/day in reducing the fungal load in brain and lung of diabetic mice. Histological studies revealed an absence of fungal elements in organs of mice treated with either AMB at 0.8 mg\/kg\/day or PSC at 60 or 80 mg\/kg\/day in both models. ITC showed limited efficacy in both models. PSC could be a therapeutic option for the treatment of systemic infections caused by\n            <jats:italic>Cunninghamella bertholletiae<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.00786-10","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T02:30:38Z","timestamp":1283221838000},"page":"4550-4555","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["<i>In Vitro<\/i>\n            and\n            <i>In Vivo<\/i>\n            Antifungal Susceptibilities of the Mucoralean Fungus\n            <i>Cunninghamella<\/i>"],"prefix":"10.1128","volume":"54","author":[{"given":"F. Javier","family":"Pastor","sequence":"first","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina I Cie\u0300ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mery","family":"Rui\u0301z-Cendoya","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina I Cie\u0300ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Pujol","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina I Cie\u0300ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Mayayo","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina I Cie\u0300ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna A.","family":"Sutton","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Guarro","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina I Cie\u0300ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01467-08"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00452-07"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00036-09"},{"key":"e_1_3_1_5_2","first-page":"43","volume":"12","year":"2008","unstructured":"Bibashi, E., V. Sidi, M. Kotsiou, E. Makrigiannaki, and D. Koliouskas. 2008. Pulmonary zygomycosis caused by Cunninghamella bertholletiae in a child with acute lymphoblastic leukemia. Hippokratia12:43-45.","journal-title":"Hippokratia"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-006-0107-1"},{"key":"e_1_3_1_7_2","unstructured":"Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard 2008"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.11.3647-3650.2003"},{"key":"e_1_3_1_9_2","unstructured":"Atlas of clinical fungi 2000"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181c2fd6d"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.126-133.2006"},{"key":"e_1_3_1_12_2","first-page":"141","volume":"144","year":"1999","unstructured":"Honda, A., K. Kamei, H. Unno, K. Hiroshima, T. Kuriyama, and M. Miyaji. 1999. A murine model of zygomycosis by Cunninghamella bertholletiae. 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