{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:59:27Z","timestamp":1780509567668,"version":"3.54.1"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"HHS | National Institutes of Health","award":["1R21AI181542-01"],"award-info":[{"award-number":["1R21AI181542-01"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2024,2,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Pneumocystis jirovecii,<\/jats:italic>\n            the fungus that causes\n            <jats:italic>Pneumocystis jirovecii<\/jats:italic>\n            pneumonia (PJP), is a leading cause of morbidity and mortality in immunocompromised individuals. We have previously shown that lung epithelial cells can bind\n            <jats:italic>Pneumocystis<\/jats:italic>\n            spp. \u03b2-glucans via the EphA2 receptor, resulting in activation and release of proinflammatory cytokines. Herein, we show that\n            <jats:italic>in vivo Pneumocystis<\/jats:italic>\n            spp. \u03b2-glucans activation of the inflammatory signaling cascade in macrophages can be pharmacodynamically inhibited with the EphA2 receptor small-molecule inhibitor ALW-II-41-27.\n            <jats:italic>In vitro<\/jats:italic>\n            , when ALW-II-41-27 is administrated via intraperitoneal to mice prior to the administration of highly proinflammatory\n            <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n            \u03b2-glucans in the lung, a significant reduction in TNF-alpha release was noted in the ALW-II-41-27 pre-treated group. Taken together, our data suggest that targeting host lung macrophage activation via EphA2 receptor-fungal \u03b2-glucans interactions with ALW-II-41-27 or other EphA2 receptor kinase targeting inhibitors might be an attractive and viable strategy to reduce detrimental lung inflammation associated with PJP.\n          <\/jats:p>","DOI":"10.1128\/aac.00811-23","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T14:01:35Z","timestamp":1704981695000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Targeting host tyrosine kinase receptor EphA2 signaling via small-molecule ALW-II-41-27 inhibits macrophage pro-inflammatory signaling responses to\n            <i>Pneumocystis carinii<\/i>\n            \u03b2-glucans"],"prefix":"10.1128","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0364-3311","authenticated-orcid":false,"given":"Theodore 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